Evidence map›Paper›PMID 22891219›Full record

Trial reportDiabetes2012

FTO genotype and 2-year change in body composition and fat distribution in response to weight-loss diets: the POUNDS LOST Trial.

Xiaomin Zhang, Qibin Qi, Cuilin Zhang, Steven R Smith, Frank B Hu, Frank M Sacks, George A Bray, Lu Qi

Erratum issued Registry-linked trialOpen access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT02519309 (Dietary Intervention in Type-2 Diabetics and Pre-Diabetics Emphasizing Personalized Carbohydrate Intake), which is not on this map. Cited by 90 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 10 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02519309 nacompletednot on this mapstarted 2015, after this paper: background citation

Dietary Intervention in Type-2 Diabetics and Pre-Diabetics Emphasizing Personalized Carbohydrate Intake

TypeinterventionalSponsorVirta HealthRan2015 to 2021Enrolled465ConditionsDiabetes Mellitus, Type 2, Pre-diabetes, Metabolic SyndromeArmsVirta Program
3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 10 syntheses or guidelines pooled it, 161 citations in OpenAlex.

  1. Pooled it
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  6. Reduction in saturated fat intake for cardiovascular disease.The Cochrane database of systematic reviews · 2020
    Pooled it
  7. Reduction in saturated fat intake for cardiovascular disease.The Cochrane database of systematic reviews · 2020
    Pooled it
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  20. FTO predicts weight regain in the Look AHEAD clinical trial.International journal of obesity (2005) · 2013
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30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Erratum issued
    Smith, Steven R [added]; Bray, George A [added]
5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Xiaomin ZhangDepartment of Nutrition, Harvard School of Public Health, Boston, MA, USA.
Qibin Qi
Cuilin Zhang
Steven R Smith
Frank B Hu
Frank M Sacks
George A Bray
Lu Qi
Brigham and Women's Hospital · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USHuazhong University of Science and Technology · CNPennington Biomedical Research Center · USTranslational Research Institute for Metabolism and Diabetes · US

Funding

Zoledronic Acid in Treatment of Osteoporosis in PostmenoM01RR002635 · NCRR · BRIGHAM AND WOMEN'S HOSPITAL · PI WILLIAMS, GORDON H · 1985 to 2008
$48.4M
Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI CORKEY, BARBARA E. · 1992 to 2021
$25.0M
Genetic Markers of CHD in Type 2 DiabetesR01HL071981 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI QI, LU · 2003 to 2012
$4.9M
Obesity Genes, Energy Regulation in Response to Weight-Loss DietsR01DK091718 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI QI, LU · 2012 to 2021
$4.5M
Genetic Determinants of ObesityZIAHD008888 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI ZHANG, CUILIN · 2009 to 2013
$133k
NCRR NIH HHS M01 RR002635NCRR NIH HHS RR-02635NHLBI NIH HHS HL071981NHLBI NIH HHS R01 HL071981NIDDK NIH HHS DK091718NIDDK NIH HHS DK46200NIDDK NIH HHS P30 DK046200NIDDK NIH HHS R01 DK091718
6 · The paper itself

Abstract

Recent evidence suggests that the fat mass and obesity-associated gene (FTO) genotype may interact with dietary intakes in relation to adiposity. We tested the effect of FTO variant on weight loss in response to 2-year diet interventions. FTO rs1558902 was genotyped in 742 obese adults who were randomly assigned to one of four diets differing in the proportions of fat, protein, and carbohydrate. Body composition and fat distribution were measured by dual-energy x-ray absorptiometry and computed tomography. We found significant modification effects for intervention varying in dietary protein on 2-year changes in fat-free mass, whole body total percentage of fat mass, total adipose tissue mass, visceral adipose tissue mass, and superficial adipose tissue mass (for all interactions, P < 0.05). Carriers of the risk allele had a greater reduction in weight, body composition, and fat distribution in response to a high-protein diet, whereas an opposite genetic effect was observed on changes in fat distribution in response to a low-protein diet. Likewise, significant interaction patterns also were observed at 6 months. Our data suggest that a high-protein diet may be beneficial for weight loss and improvement of body composition and fat distribution in individuals with the risk allele of the FTO variant rs1558902.

Indexed as

Body Fat DistributionPolymorphism, Single NucleotideAdultAlpha-Ketoglutarate-Dependent Dioxygenase FTOBody CompositionBody Mass IndexBostonDietary ProteinsDiet, ReducingFemaleGenetic Association StudiesHeterozygoteHumansLouisianaMaleMiddle AgedAlpha-Ketoglutarate-Dependent Dioxygenase FTODietary ProteinsFTO protein, humanProteins

Identifiers

PMID22891219
PMCPMC3478519
OpenAlexW2123327495

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.