SynthesisCanadian journal of gastroenterology = Journal canadien de gastroenterologie2012
Why do mortality rates for nonvariceal upper gastrointestinal bleeding differ around the world? A systematic review of cohort studies.
Synthesis in Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Summary of the best evidence for stress ulcer prophylaxis in critically ill patients.Frontiers in medicine · 2026Pooled it
- Prophylactic transcatheter arterial embolization reduces rebleeding in non-variceal upper gastrointestinal bleeding: A meta-analysis.World journal of gastroenterology · 2021Pooled it
- Genetic polymorphisms associated with upper gastrointestinal bleeding: a systematic review.The pharmacogenomics journal · 2021Pooled it
- Guidelines for the prevention and treatment of stress ulcers in critically ill patients (2026).Journal of intensive medicine · 2026Article
- Prognostic Value of the Neutrophil Percentage-to-Albumin Ratio in Acute Non-Variceal Upper Gastrointestinal Bleeding.Journal of clinical medicine · 2026Article
- Explainable machine learning predicts mortality in critically ill patients with nonvariceal upper gastrointestinal bleeding: a MIMIC-IV study with external validation.BMC gastroenterology · 2026Article
- Smoking and the Bleeding Gut: Impact on 30-Day Readmission with Recurrent Non-variceal Upper GI Hemorrhage.Digestive diseases and sciences · 2025Observational
- Low Cholesterol Concentrations and the Risk of Peptic Ulcer Bleeding: A Retrospective Cohort Study.Journal of clinical medicine · 2025Article
- Article
- Impact of Timing of Endoscopy on Mortality in Non-variceal Upper Gastrointestinal Bleeding: A Retrospective Cohort Study :.Galen medical journal · 2025Article
- Upper Gastrointestinal Bleeding: A Retrospective, Single-Center Experience on the Role of Endoscopy and Outcomes.Journal of clinical medicine research · 2025Article
- Clinical outcomes of nonvariceal upper gastrointestinal bleeding in nonagenarians and octogenarians: a comparative nationwide analysis.Clinical endoscopy · 2024Article
- Long-Term Outcomes following Acute Upper Gastrointestinal Bleeding Remain Poor: A Single-Center Comparison over Two Distinct Time Periods within the Last 15 Years in Finland.Visceral medicine · 2024Article
- Trends for Admission, Mortality and Emergency Surgery in Upper Gastrointestinal Bleeding: A Study of Eight Years of Admissions in a Tertiary Care Hospital.International journal of general medicine · 2024Article
- Comparison of mechanical and thermal therapy in upper gastrointestinal bleeding: an analysis of efficacy outcomes.Proceedings (Baylor University. Medical Center) · 2024Article
- Magnetically controlled capsule for assessment of the gastric mucosa in symptomatic patients: a prospective, single-arm, single-center, comparative study.iGIE : innovation, investigation and insights · 2023Article
- The Reduction of After-Hours and Weekend Effects in Upper Gastro-intestinal Bleeding Mortality During the COVID-19 Pandemic Compared to the Pre-Pandemic Period.Journal of multidisciplinary healthcare · 2023Article
- Synergism interaction between genetic polymorphisms in drug metabolizing enzymes and NSAIDs on upper gastrointestinal haemorrhage: a multicenter case-control study.Annals of medicine · 2022Article
- A Novel Prediction Tool for Endoscopic Intervention in Patients with Acute Upper Gastro-Intestinal Bleeding.Journal of clinical medicine · 2022Article
- Can neutrophil-lymphocyte ratio predict mortality in acute non-variceal upper gastrointestinal bleeding?Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiscrepancies exist in reported mortality rates of nonvariceal upper gastrointestinal bleeding (NVUGIB).
objectiveTo perform a systematic review assessing possible reasons for these disparate findings and to more reliably compare them.
methodsThe MEDLINE, EMBASE and ISI Web of Knowledge databases were searched for studies reporting mortality rates in NVUGIB involving adults and published in English. To ensure robust and contemporary estimates, studies spanning 1996 to January 2011 that included more than 1000 patients were selected.
resultsEighteen of 3077 studies were selected. Ten studies used administrative databases and the remaining eight used registries. The mortality rates reported in these studies ranged from 1.1% in Japan to 11% in Denmark. There were variations in reported mortality rates among countries and also within countries. Reasons for these disparities included a spectrum of quality in reporting as well as heterogeneous definitions of case ascertainment, differing patient populations with regard to severity of presentation and associated comorbidities, varying durations of follow-up and different health care system-related practices.
conclusionsWide differences in reported NVUGIB mortality rates are attributable to differences in adopted methodologies and populations studied. More uniform standards in reporting are needed; only then can true observed variations enable a better understanding of causes of death and pave the way to improved patient outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.