Evidence map›Paper›PMID 22891107›Full record

ReviewMethodist DeBakey cardiovascular journal2012

Magnetically targeted delivery of therapeutic agents to injured blood vessels for prevention of in-stent restenosis.

Michael Chorny, Ilia Fishbein, Richard F Adamo, Scott P Forbes, Zoë Folchman-Wagner, Ivan S Alferiev

Open access · diamondAbstract readReview
In one paragraph

Review in Methodist DeBakey cardiovascular journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Magnetic Cell Targeting for Cardiovascular Tissue Engineering.Tissue engineering. Part B, Reviews · 2025
    Review
  2. Retinoid-impregnated nanoparticles enable control of bone growth by site-specific modulation of endochondral ossification in mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Site-specific gene delivery to stented arteries using magnetically guided zinc oleate-based nanoparticles loaded with adenoviral vectors.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Michael ChornyDivision of Cardiology Research, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Ilia Fishbein
Richard F Adamo
Scott P Forbes
Zoë Folchman-Wagner
Ivan S Alferiev
Children's Hospital of Philadelphia · US

Funding

Training in Molecular Therapeutics for Pediatric CardiologyT32HL007915 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI Robert J Levy, JOSEPH W ROSSANO · 1999 to 2026
$13.4M
Gene Delivery StentsR01HL072108 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI LEVY, ROBERT J · 2003 to 2013
$3.9M
Gene Delivery Stents AAV FormulationsR56HL072108 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI FISHBEIN, ILIA, LEVY, ROBERT J · 2015 to 2015
$420k
NHLBI NIH HHS HL72108NHLBI NIH HHS R01 HL072108NHLBI NIH HHS T32 HL007915
6 · The paper itself

Abstract

Magnetic guidance is a physical targeting strategy with the potential to improve the safety and efficacy of a variety of therapeutic agents--including small-molecule pharmaceuticals, proteins, gene vectors, and cells--by enabling their site-specific delivery. The application of magnetic targeting for in-stent restenosis can address the need for safer and more efficient treatment strategies. However, its translation to humans may not be possible without revising the traditional magnetic targeting scheme, which is limited by its inability to selectively guide therapeutic agents to deep localized targets. An alternative two-source strategy can be realized through the use of uniform, deep-penetrating magnetic fields in conjunction with vascular stents included as part of the magnetic setup and the platform for targeted delivery to injured arteries. Studies showing the feasibility of this novel targeting strategy in in-stent restenosis models and considerations in the design of carrier formulations for magnetically guided antirestenotic therapy are discussed in this review.

Indexed as

MagneticsStentsAngioplastyAnimalsArterial Occlusive DiseasesCardiovascular AgentsConstriction, PathologicCoronary RestenosisDrug Delivery SystemsHumansProsthesis DesignRecurrenceCardiovascular Agentsbiodegradable nanoparticledrug deliverygene therapymagnetic targetingrestenosisstent angioplastyvascular disease

Identifiers

PMID22891107
PMCPMC3405781
OpenAlexW2079040635

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.