ArticleFrontiers in genetics2012
Biphasic patterns of diversification and the emergence of modules.
Article in Frontiers in genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
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- Tracing the birth of structural domains from loops during protein evolution.Scientific reports · 2023Article
- The rise of hierarchy and modularity in biological networks explained by empedocles' double tale ∼2,400 years before darwin and systems biology.Frontiers in genetics · 2022Article
- Evolution of networks of protein domain organization.Scientific reports · 2021Article
- Menzerath-Altmann's Law of Syntax in RNA Accretion History.Life (Basel, Switzerland) · 2021Article
- Emergence of Hierarchical Modularity in Evolving Networks Uncovered by Phylogenomic Analysis.Evolutionary bioinformatics online · 2019Review
- Article
- Evolution of macromolecular structure: a 'double tale' of biological accretion and diversification.Science progress · 2018Review
- Piecemeal Buildup of the Genetic Code, Ribosomes, and Genomes from Primordial tRNA Building Blocks.Life (Basel, Switzerland) · 2016Article
- A Dynamic Model for the Evolution of Protein Structure.Journal of molecular evolution · 2016Article
- The early history and emergence of molecular functions and modular scale-free network behavior.Scientific reports · 2016Article
- Computing the origin and evolution of the ribosome from its structure - Uncovering processes of macromolecular accretion benefiting synthetic biology.Computational and structural biotechnology journal · 2015Review
- Archaea: the first domain of diversified life.Archaea (Vancouver, B.C.) · 2014Review
- A calibrated chronology of biochemistry reveals a stem line of descent responsible for planetary biodiversity.Frontiers in genetics · 2014Article
- A general framework of persistence strategies for biological systems helps explain domains of life.Frontiers in genetics · 2013Article
- Structural phylogenomics retrodicts the origin of the genetic code and uncovers the evolutionary impact of protein flexibility.PloS one · 2013Article
- Benefits of using molecular structure and abundance in phylogenomic analysis.Frontiers in genetics · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intricate molecular and cellular structure of organisms converts energy to work, which builds and maintains structure. Evolving structure implements modules, in which parts are tightly linked. Each module performs characteristic functions. In this work we propose that a module can emerge through two phases of diversification of parts. Early in the first phase of this biphasic pattern, the parts have weak linkage-they interact weakly and associate variously. The parts diversify and compete. Under selection for performance, interactions among the parts increasingly constrain their structure and associations. As many variants are eliminated, parts self-organize into modules with tight linkage. Linkage may increase in response to exogenous stresses as well as endogenous processes. In the second phase of diversification, variants of the module and its functions evolve and become new parts for a new cycle of generation of higher-level modules. This linkage hypothesis can interpret biphasic patterns in the diversification of protein domain structure, RNA and protein shapes, and networks in metabolism, codes, and embryos, and can explain hierarchical levels of structural organization that are widespread in biology.
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