ArticleCerebral cortex (New York, N.Y. : 1991)2013
Sexual dimorphism in the human corpus callosum: an MRI study using the OASIS brain database.
Article in Cerebral cortex (New York, N.Y. : 1991), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 120 citations in OpenAlex.
- Sex differences in brain homotopic co-activations: a meta-analytic study.Brain structure & function · 2022Pooled it
- Meta-analysis of regional white matter volume in bipolar disorder with replication in an independent sample using coordinates, T-maps, and individual MRI data.Neuroscience and biobehavioral reviews · 2018Pooled it
- Effects of different intracranial volume correction methods on univariate sex differences in grey matter volume and multivariate sex prediction.Scientific reports · 2020Trial
- SliceMap: a binary classification-driven 2D pipeline for detecting discriminative candidate regions in brain MRI.Frontiers in neuroimaging · 2026Article
- Article
- The normalizing properties of intracranial volume across race and sex.Brain communications · 2025Article
- WhiFuN: A toolbox to map the white matter functional networks of the human brain.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Sex Differences in Human Brain Structure at Birth.Biology of sex differences · 2024Article
- Sex-related variability of white matter tracts in the whole HCP cohort.Brain structure & function · 2024Article
- Article
- Corpus Callosum Volumes in Children with Autism Spectrum Disorders: Sex-Associated Differences.Journal of autism and developmental disorders · 2023Article
- Sex/Gender Differences in Brain Lateralisation and Connectivity.Current topics in behavioral neurosciences · 2023Article
- Spectral-based thickness profiling of the corpus callosum enhances anomaly detection in fetal alcohol spectrum disorders.Frontiers in neuroscience · 2023Article
- Prediction of subjective cognitive decline after corpus callosum infarction by an interpretable machine learning-derived early warning strategy.Frontiers in neurology · 2023Article
- A Volumetric Study of the Corpus Callosum in the Turkish Population.Journal of neurological surgery. Part B, Skull base · 2022Article
- Individual variability in the nonlinear development of the corpus callosum during infancy and toddlerhood: a longitudinal MRI analysis.Brain structure & function · 2022Article
- Article
- Structural properties of corpus callosum are associated differently with verbal creativity and visual creativity.Brain structure & function · 2021Article
- ADVIAN: Alzheimer's Disease VGG-Inspired Attention Network Based on Convolutional Block Attention Module and Multiple Way Data Augmentation.Frontiers in aging neuroscience · 2021Article
- Extraction and Evaluation of Corpus Callosum from 2D Brain MRI Slice: A Study with Cuckoo Search Algorithm.Computational and mathematical methods in medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
A number of studies have reported that, "relative to brain size," the midsagittal corpus callosum cross-sectional area (CCA) in females is on average larger than in males. However, others suggest that these may be spurious differences created in the CCA-to-brain-size ratio because brain size tends to be larger in males. To help resolve this controversy, we measured the CCA on all 316 magnetic resonance imaging (MRI) scans of normal subjects (18-94 years) in the OASIS (Open Access Series of Imaging Studies) cross-sectional dataset, and used multiple regression analysis to statistically control for the confounding effects of brain size and age to test the null hypothesis that the average CCA is not different between genders. An additional analysis was performed on a subset of 74 young adults (37 males and 37 females; 18-29 years) matched closely to brain size. Our null hypothesis was rejected in both analyses. In the entire sample (n= 316), controlling for brain size and age, the average CCA was significantly (P< 0.03) larger in females. The difference favoring females was more pronounced in the young adults cohort (P< 0.0005). These results provide strong additional evidence that the CCA is larger in females after correcting for the confounding effect of brain size.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.