ArticleAntimicrobial agents and chemotherapy2012
Streptococcus pneumoniae transposon Tn1545/Tn6003 changes to Tn6002 due to spontaneous excision in circular form of the erm(B)- and aphA3-containing macrolide-aminoglycoside-streptothricin (MAS) element.
Article in Antimicrobial agents and chemotherapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- Multidrug resistance in group BJournal of medical microbiology · 2025Article
- Circular intermediate-mediated horizontal transfer of the chromosome-encodedFrontiers in microbiology · 2023Article
- Studies on the Transmission of a Tigecycline Resistance-MediatingMicrobiology spectrum · 2022Article
- Transferable Resistance GeneAntimicrobial agents and chemotherapy · 2020Article
- Presence and Characterization of a NovelFrontiers in microbiology · 2020Article
- Unexpected relationships between frequency of antimicrobial resistance, disease phenotype andMicrobial genomics · 2019Article
- Genomics and Genetics ofMicrobiology spectrum · 2019Review
- Antimicrobial Resistance, Virulence Determinants, and Biofilm Formation ofFrontiers in microbiology · 2019Article
- Comparative genomics of Enterococcus spp. isolated from bovine feces.BMC microbiology · 2017Article
- Article
- Diversity and Evolution of the Tn5801-tet(M)-Like Integrative and Conjugative Elements among Enterococcus, Streptococcus, and Staphylococcus.Antimicrobial agents and chemotherapy · 2016Article
- Determination of Characteristics of Erythromycin Resistant Streptococcus pneumoniae with Preferred PCV Usage in Iran.PloS one · 2016Article
- Composite mobile genetic elements disseminating macrolide resistance in Streptococcus pneumoniae.Frontiers in microbiology · 2015Article
- Variation on a theme; an overview of the Tn916/Tn1545 family of mobile genetic elements in the oral and nasopharyngeal streptococci.Frontiers in microbiology · 2014Review
- Pitfalls encountered while investigating genetic elements by PCR.Mobile genetic elements · 2013Article
- Unconventional circularizable bacterial genetic structures carrying antibiotic resistance determinants.Antimicrobial agents and chemotherapy · 2013Article
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5 authors.
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Abstract
The macrolide-aminoglycoside-streptothricin (MAS) element, an ∼4.2-kb insertion containing erm(B) and aphA3 resistance determinants, distinguishes Streptococcus pneumoniae transposon Tn1545/Tn6003 from Tn6002. Here, it is shown to be an unstable genetic element that, although it lacks recombinase genes, can exploit long, erm(B)-containing direct repeats acting as att sites for spontaneous excision that may result in loss. Consequent to excision, which is RecA independent, Tn1545/Tn6003 changes to Tn6002. In pneumococcal populations harboring Tn1545/Tn6003, the latter appears to coexist with Tn6002.
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