ArticleThe Journal of physiology2012
Altered pallido-pallidal synaptic transmission leads to aberrant firing of globus pallidus neurons in a rat model of Parkinson's disease.
Article in The Journal of physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.
- Connectivity and Functionality of the Globus Pallidus Externa Under Normal Conditions and Parkinson's Disease.Frontiers in neural circuits · 2021Pooled it
- Temporal Variability in the Spiking Activity of Neurons in the External Globus Pallidus in Healthy and Parkinsonian Monkeys.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- In silico model of basal ganglia deep brain stimulation in Parkinson's disease captures range of effective parameters for pathological beta power suppression.PLoS computational biology · 2026Article
- Calcium-based synaptic and structural plasticity link pathological activity to synaptic reorganization in Parkinson's disease.Science advances · 2025Article
- Cellular and synaptic properties of molecularly defined neurons in the external globus pallidus.iScience · 2025Article
- Neuronal and network resonance in the external globus pallidus.Journal of neurophysiology · 2025Article
- Unraveling the Complexity of Parkinson's Disease: Insights into Pathogenesis and Precision Interventions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Synaptic Changes in Pallidostriatal Circuits Observed in the Parkinsonian Model Triggers Abnormal Beta Synchrony with Accurate Spatio-temporal Properties across the Basal Ganglia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Spatiomolecular Characterization of Dopamine D2 Receptors Cells in the Mouse External Globus Pallidus.Current neuropharmacology · 2024Article
- Coordinated reset stimulation of plastic neural networks with spatially dependent synaptic connections.Frontiers in network physiology · 2024Article
- Dynamics of parkinsonian oscillations mediated by transmission delays in a mean-field model of the basal ganglia.Frontiers in cellular neuroscience · 2024Article
- Sexual differences in locus coeruleus neurons and related behavior in C57BL/6J mice.Biology of sex differences · 2023Article
- The indirect pathway of the basal ganglia promotes transient punishment but not motor suppression.Neuron · 2023Article
- The network configuration in Parkinsonian state compensates network activity change caused by loss of dopamine.Physiological reports · 2023Article
- Synaptic network structure shapes cortically evoked spatio-temporal responses of STN and GPe neurons in a computational model.Frontiers in neuroinformatics · 2023Article
- Model-based optogenetic stimulation to regulate beta oscillations in Parkinsonian neural networks.Cognitive neurodynamics · 2022Article
- Biophysical and Architectural Mechanisms of Subthalamic Theta under Response Conflict.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Spike-Timing-Dependent Plasticity Mediated by Dopamine and its Role in Parkinson's Disease Pathophysiology.Frontiers in network physiology · 2022Review
- Inhibitory Spike-Timing-Dependent Plasticity Can Account for Pathological Strengthening of Pallido-Subthalamic Synapses in Parkinson's Disease.Frontiers in physiology · 2022Article
- Population-specific neuromodulation prolongs therapeutic benefits of deep brain stimulation.Science (New York, N.Y.) · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pattern of activity of globus pallidus (GP) neurons is tightly regulated by GABAergic inhibition. In addition to extrinsic inputs from the striatum (STR-GP) the other source of GABA to GP neurons arises from intrinsic intranuclear axon collaterals (GP-GP). While the contribution of striatal inputs has been studied, notably its hyperactivity in Parkinson's disease (PD), the properties and function of intranuclear inhibition remain poorly understood. Our objective was therefore to test the impact of chronic dopamine depletion on pallido-pallidal transmission. Using patch-clamp whole-cell recordings in rat brain slices, we combined electrical and optogenetic stimulations with pharmacology to differentiate basic synaptic properties of STR-GP and GP-GP GABAergic synapses. GP-GP synapses were characterized by activity-dependent depression and insensitivity to the D(2) receptor specific agonist quinpirole and STR-GP synapses by frequency-dependent facilitation and quinpirole modulation. Chronic dopamine deprivation obtained in 6-OHDA lesioned animals boosted the amplitude of GP-GP IPSCs but did not modify STR-GP transmission and increased the amplitude of miniature IPSCs. Replacement of calcium by strontium confirmed that the quantal amplitude was increased at GP-GP synapses. Finally, we demonstrated that boosted GP-GP transmission promotes resetting of autonomous activity and rebound-burst firing after dopamine depletion. These results suggest that GP-GP synaptic transmission (but not STR-GP) is augmented by chronic dopamine depletion which could contribute to the aberrant GP neuronal activity observed in PD.
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