SynthesisJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2012
Meta-analysis of the results of randomized controlled trials that compared laparoscopic and open surgery for acute appendicitis.
Synthesis in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 13 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 13 syntheses or guidelines pooled it, 132 citations in OpenAlex.
- Laparoscopic versus robotic abdominal and pelvic surgery: a systematic review of randomised controlled trials.Surgical endoscopy · 2023Pooled it
- Laparoscopic versus open surgery for adhesional small bowel obstruction: a systematic review and meta-analysis of case-control studies.Surgical endoscopy · 2019Pooled it
- Laparoscopic appendicectomy is superior to open surgery for complicated appendicitis.Surgical endoscopy · 2019Pooled it
- Laparoscopic Repair for Perforated Peptic Ulcer Disease Has Better Outcomes Than Open Repair.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2019Pooled it
- Laparoscopic versus open surgery for suspected appendicitis.The Cochrane database of systematic reviews · 2018Pooled it
- Methodological overview of systematic reviews to establish the evidence base for emergency general surgery.The British journal of surgery · 2017Pooled it
- The current management of acute uncomplicated appendicitis: should there be a change in paradigm? A systematic review of the literatures and analysis of treatment performance.World journal of emergency surgery : WJES · 2017Pooled it
- Diagnosis and management of acute appendicitis. EAES consensus development conference 2015.Surgical endoscopy · 2016Guideline
- Meta-analysis of antibiotics versus appendicectomy for non-perforated acute appendicitis.The British journal of surgery · 2016Pooled it
- Evidence of surgical outcomes fluctuates over time: results from a cumulative meta-analysis of laparoscopic versus open appendectomy for acute appendicitis.BMC gastroenterology · 2016Pooled it
- Single-incision laparoscopic appendectomy versus conventional 3-port laparoscopic appendectomy for appendicitis: an updated meta-analysis of randomized controlled trials.Surgery today · 2015Pooled it
- Laparoscopic versus open appendectomy in patients with suspected appendicitis: a systematic review of meta-analyses of randomised controlled trials.BMC gastroenterology · 2015Pooled it
- Single-incision versus conventional laparoscopic appendectomy: a meta-analysis of randomized controlled trials.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2014Pooled it
- Single versus double Hem-o-lok clips to secure the apendiceal stump during laparoscopic appendectomy: a prospective randomized multicentric clinical trial.Langenbeck's archives of surgery · 2024Trial
- Telestration with augmented reality improves surgical performance through gaze guidance.Surgical endoscopy · 2023Trial
- A randomized clinical trial of technical modifications of appendix stump closure during laparoscopic appendectomy for uncomplicated acute appendicitis.BMC surgery · 2021Trial
- Trial
- Single-port laparoscopic surgery in uncomplicated acute appendicitis: a randomized controlled trial.Surgical endoscopy · 2018Trial
- Clinical Efficacy of Standardized Care for Abdominal Drainage Tubes in the Treatment of Acute Appendicitis: A Single-Center Retrospective Cohort Study.Emergency medicine international · 2026Article
- Laparoscopic appendectomy as the gold standard: What role remains for open surgery, conversion, and disease severity? : An analysis of 32,000 cases with appendicitis in Germany.World journal of emergency surgery : WJES · 2025Observational
8 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe conducted a meta-analysis to evaluate and compare the outcomes of laparoscopic and open surgery for the treatment of patients with acute appendicitis.
methodsWe searched MEDLINE, EMBASE, Science Citation Index, and the Cochrane Controlled Trial Register for relevant papers published between January 1990 and February 2012. We analyzed 22 outcomes of laparoscopic and open surgery for acute appendicitis.
resultsWe identified 39 papers reporting results from randomized controlled trials that compared laparoscopic surgery with open surgery for acute appendicitis. Our meta-analysis included 5,896 patients with acute appendicitis; 2,847 had undergone laparoscopic surgery, and 3,049 had undergone open surgery. Compared with open surgery, laparoscopic surgery was associated with longer operative time (by 13.12 min). However, compared with open surgery, laparoscopic surgery for acute appendicitis was associated with earlier resumption of liquid and solid intake; shorter duration of postoperative hospital stay; a reduction in dose numbers of parenteral and oral analgesics; earlier return to normal activity, work, and normal life; decreased occurrence of wound infection; a better cosmesis; and similar hospital charges.
conclusionsLaparoscopic surgery may now be the standard treatment for acute appendicitis.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.