ReviewInflammation research : official journal of the European Histamine Research Society ... [et al.]2012
Environmental and non-infectious factors in the aetiology of pharyngitis (sore throat).
Review in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05955885 (Effect of Over-the-counter Non-steroidal Anti-inflammatory Treatments on Cough Reflex Sensitivity in Subjects with Upper Respiratory Tract Infection), which is not on this map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Over-the-counter Non-steroidal Anti-inflammatory Treatments on Cough Reflex Sensitivity in Subjects with Upper Respiratory Tract Infection
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.
- Clinical Practice Guideline: Sore Throat.Deutsches Arzteblatt international · 2021Guideline
- Comparative Effects of Flurbiprofen and Benzydamine on COX-2/PGEInternational journal of molecular sciences · 2026Article
- Impact of Oropharyngeal Packing on Postoperative Nausea, Vomiting, and Throat Discomfort: A Systematic Review and Meta-Analysis.Dentistry journal · 2026Review
- Article
- Efficacy of Locally Applied Flurbiprofen in Sore Throat Treatment: A Scoping Review.Biomedicines · 2025Review
- Longitudinal Symptom Analysis of COVID-19 Survivors and Post-COVID Syndrome Patients.Biomedicines · 2025Article
- Development and refinement of the sore throat pain model as an assay for measuring therapeutic effects on acute pain.Frontiers in pain research (Lausanne, Switzerland) · 2025Review
- Dynamic Risk Status of OSA and Its Association with COPD Incidence and Progression to Oxygen Therapy: Insights from a US National Cohort.International journal of chronic obstructive pulmonary disease · 2025Article
- A pharynx-to-brain axis controls pharyngeal inflammation-induced anxiety.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Ent Manifestations in Sculptors of South Chennai, India: A Cross Sectional Observational Study.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- Comorbidities in COPD: Current and Future Treatment Challenges.Journal of clinical medicine · 2024Review
- Exploring the Action Mechanism and Validation of the Key Pathways ofCombinatorial chemistry & high throughput screening · 2024Article
- The effects of greater frequency of two most prevalent bothersome acute respiratory symptoms on health-related quality of life in the 2020 US general population.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Article
- Article
- Prevalence, Antibiotic Susceptibility Profile and Associated Factors of Group A Streptococcal pharyngitis Among Pediatric Patients with Acute Pharyngitis in Gondar, Northwest Ethiopia.Infection and drug resistance · 2023Article
- Bidirectional relationships of comorbidity with obstructive sleep apnoea.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Non-interventional Pilot Study Evaluating the Efficacy and Safety of Lysozymebased Therapy in Patients with Non-infectious Sore Throat.Acta medica academica · 2022Article
- [Sore Throat - Guideline-based Diagnostics and Therapy].ZFA. Zeitschrift fur Allgemeinmedizin · 2022Article
- The Toxicity of Wiped Dust and Airborne Microbes in Individual Classrooms Increase the Risk of Teachers' Work-Related Symptoms: A Cross-Sectional Study.Pathogens (Basel, Switzerland) · 2021Article
- Bitter Taste Disrupts Spatial Discrimination of Piperine-Evoked Burning Sensations: A Pilot Study.Biology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this review is to examine the causes, pathophysiology and experimental models of non-infectious pharyngitis (sore throat).
introductionThe causes of sore throat can be infectious (viruses, bacteria, and fungi) or non-infectious, although the relative proportion of each is not well documented.
methodsA PubMed database search was performed for studies of non-infectious sore throat. RESULTS AND
conclusionsNon-infectious causes of sore throat include: physico-chemical factors, such as smoking, snoring, shouting, tracheal intubation, medications, or concomitant illness; and environmental factors including indoor and outdoor air pollutants, temperature and humidity, and hazardous or occupational irritants. The pathophysiology underlying non-infectious sore throat is largely uncharacterised, although neurogenic inflammation looks to be a promising candidate. It is likely that there will be individual disposition factors or the coincidence of more than one irritant with possible--up to now unknown--interactions between them. Therefore, experimental models with defined conditions and objective endpoints are needed. A new model using cold dry air to directly induce pharyngeal irritation in humans, with pharyngeal lavage to measure biomarkers, may provide a useful tool for the study of mechanisms and treatment of non-infectious sore throat.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.