ArticleInternational urogynecology journal2013
The familiality of pelvic organ prolapse in the Utah Population Database.
Article in International urogynecology journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Review
- Family size for women with primary ovarian insufficiency and their relatives.Human reproduction (Oxford, England) · 2023Article
- Primary ovarian insufficiency has strong familiality: results of a multigenerational genealogical study.Fertility and sterility · 2023Article
- Common variants in LAMC1 confer risk for pelvic organ prolapse in Chinese population.Hereditas · 2020Article
- Is levator hiatus distension associated with peripheral ligamentous laxity during pregnancy?International urogynecology journal · 2017Article
- Ancestry Testing and the Practice of Genetic Counseling.Journal of genetic counseling · 2017Review
- Evidence for pelvic organ prolapse predisposition genes on chromosomes 10 and 17.American journal of obstetrics and gynecology · 2015Article
- Clinical characteristics of women with familial pelvic floor disorders.International urogynecology journal · 2015Article
- Genetic Determinants of Pelvic Organ Prolapse among African American and Hispanic Women in the Women's Health Initiative.PloS one · 2015Article
- Phenotyping clinical disorders: lessons learned from pelvic organ prolapse.American journal of obstetrics and gynecology · 2013Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
introduction and hypothesisPelvic organ prolapse (POP) in women is a common condition whose etiology is poorly understood. There is increasing evidence that POP is heritable. The aim of our study was to define and evaluate familial clustering of POP.
methodsUsing a population-based Utah genealogy linked to more than a decade of hospital data, we calculated relative risks (RR) of POP in female relatives of women with POP using age- and birth year-specific rates of POP. We compared the average pairwise relatedness of all POP cases to the population using a measure of genetic distance.
resultsWe identified 1,292 women with diagnostic and procedure codes for POP. The RR of POP was significantly elevated in first- and third-degree female relatives (RR 4.15, p < 0.001; RR 1.24, p = 0.05). The average pairwise relatedness for all individuals with POP was significantly higher than expected (p < 0.001).
conclusionsThese results strongly support a significant heritable contribution to POP.
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