ArticleBlood transfusion = Trasfusione del sangue2012
Red blood cell microparticles and blood group antigens: an analysis by flow cytometry.
Article in Blood transfusion = Trasfusione del sangue, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Red Blood Cell-Derived Extracellular Vesicles: An Overview of Current Research Progress, Challenges, and Opportunities.Biomedicines · 2023Review
- Membrane Cholesterol Enrichment of Red Blood Cell-Derived Microparticles Results in Prolonged Circulation.ACS applied bio materials · 2022Article
- Rhesus D Antigenic Determinants on Residual Red Blood Cells in Apheresis and Buffy Coat Platelet Concentrates.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2020Article
- Article
- Protect, repair, destroy or sacrifice: a role of oxidative stress biology in inter-donor variability of blood storage?Blood transfusion = Trasfusione del sangue · 2019Review
- Exposure to non-inherited maternal antigens by breastfeeding affects antibody responsiveness.Haematologica · 2019Article
- Platelet Transfusion Induces Alloimmunization to D and Non-D Rhesus Antigens.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2018Article
- Platelet-, leucocyte- and red cell-derived microparticles in stored whole blood, with and without leucofiltration, with and without ionising radiation.Blood transfusion = Trasfusione del sangue · 2018Article
- Large Extracellular Vesicles: Have We Found the Holy Grail of Inflammation?Frontiers in immunology · 2018Review
- Influence of red blood cell-derived microparticles upon vasoregulation.Blood transfusion = Trasfusione del sangue · 2017Review
- Duration of red blood cell storage and inflammatory marker generation.Blood transfusion = Trasfusione del sangue · 2017Review
- Isolation and Characterization of Microvesicles from Peripheral Blood.Journal of visualized experiments : JoVE · 2017Article
- Physiologic Impact of Circulating RBC Microparticles upon Blood-Vascular Interactions.Frontiers in physiology · 2017Review
- Effect of Irradiation on Microparticles in Red Blood Cell Concentrates.Annals of laboratory medicine · 2016Article
- Classic and alternative red blood cell storage strategies: seven years of "-omics" investigations.Blood transfusion = Trasfusione del sangue · 2015Review
- Deoxygenation of leucofiltered erythrocyte concentrates preserves proteome stability during storage in the blood bank.Blood transfusion = Trasfusione del sangue · 2014Article
- Are microparticles the missing link between thrombosis and autoimmune diseases? Involvement in selected rheumatologic diseases.Seminars in thrombosis and hemostasis · 2014Review
- Erythrocyte-derived microparticles supporting activated protein C-mediated regulation of blood coagulation.PloS one · 2014Article
- Red blood cell vesiculation in hereditary hemolytic anemia.Frontiers in physiology · 2013Review
- Shaking hands with the future through omics application in transfusion medicine and clinical biochemistry.Blood transfusion = Trasfusione del sangue · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe storage of blood induces the formation of erythrocytes-derived microparticles. Their pathogenic role in blood transfusion is not known so far, especially the risk to trigger alloantibody production in the recipient. This work aims to study the expression of clinically significant blood group antigens on the surface of red blood cells microparticles. MATERIAL AND
methodsRed blood cells contained in erythrocyte concentrates were stained with specific antibodies directed against blood group antigens and routinely used in immunohematology practice. After inducing erythrocytes vesiculation with calcium ionophore, the presence of blood group antigens was analysed by flow cytometry.
resultsThe expression of several blood group antigens from the RH, KEL, JK, FY, MNS, LE and LU systems was detected on erythrocyte microparticles. The presence of M (MNS1), N (MNS2) and s (MNS4) antigens could not be demonstrated by flow cytometry, despite that glycophorin A and B were identified on microparticles using anti-CD235a and anti-MNS3. DISCUSSION: We conclude that blood group antigens are localized on erythrocytes-derived microparticles and probably keep their immunogenicity because of their capacity to bind specific antibody. Selective segregation process during vesiculation or their ability to elicit an immune response in vivo has to be tested by further studies.
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