ReviewTrends in microbiology2012
Non-genetic diversity shapes infectious capacity and host resistance.
Review in Trends in microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Review
- Transcriptional diversification in a human-adapting zoonotic pathogen drives niche-specific evolution.Nature communications · 2025Article
- Detection of virulence factors in opportunistic bacteria: advances, challenges, and practical implementation.Frontiers in microbiology · 2025Review
- Rapid evolution of an adaptive multicellular morphology of Candida auris during systemic infection.Nature communications · 2024Article
- Dual-Fluorescence Chromosome-Located Labeling System for Accurate In Vivo Single-Cell Gene Expression Analysis in Pseudomonas syringae.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Article
- Evasion of toll-like receptor recognition byFrontiers in microbiology · 2023Article
- Bacteriophage-antibiotic combination therapy against extensively drug-resistant Pseudomonas aeruginosa infection to allow liver transplantation in a toddler.Nature communications · 2022Article
- Genome instability drives epistatic adaptation in the human pathogenProceedings of the National Academy of Sciences of the United States of America · 2021Article
- For the Greater (Bacterial) Good: Heterogeneous Expression of Energetically Costly Virulence Factors.Infection and immunity · 2020Review
- Two Tandem Mechanisms Control Bimodal Expression of the Flagellar Genes in Salmonella enterica.Journal of bacteriology · 2020Article
- Bimodal Expression of theGenetics · 2018Article
- Article
- Confocal microscopy reveals in planta dynamic interactions between pathogenic, avirulent and non-pathogenic Pseudomonas syringae strains.Molecular plant pathology · 2018Article
- Involvement of Two-Component Signaling on Bacterial Motility and Biofilm Development.Journal of bacteriology · 2017Review
- Resolving host-pathogen interactions by dual RNA-seq.PLoS pathogens · 2017Review
- A bacterial global regulator forms a prion.Science (New York, N.Y.) · 2017Article
- Spontaneous mutations in the flhD operon generate motility heterogeneity in Escherichia coli biofilm.BMC microbiology · 2016Article
- Direct Correlation between Motile Behavior and Protein Abundance in Single Cells.PLoS computational biology · 2016Article
- Evasion and interference: intracellular pathogens modulate caspase-dependent inflammatory responses.Nature reviews. Microbiology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The spontaneous generation of distinct phenotypes within a clonal population of cells allows for both bet-hedging at the population level and the division of labor among subpopulations. This is emerging as an important theme in bacterial pathogenesis, because bacterial pathogens exhibit phenotypic heterogeneity with respect to characteristics that impact virulence. The phenomenon of persister cells and models of Salmonella enterica serovar Typhimurium (S. Typhimurium) pathogenesis illustrate the importance of non-genetic diversity in the disease process. Such heterogeneity can arise from specific genetic architectures amplifying stochastic fluctuations in factors affecting gene expression, and this also drives variation in eukaryotic cells. Thus reproducible variation in both host and pathogen processes affects the outcome of infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.