ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2012
The genome of the heartworm, Dirofilaria immitis, reveals drug and vaccine targets.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 1 of them a synthesis that pooled it.
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Who cites it
80 citing papers in PubMed, 1 synthesis or guideline pooled it.
- What helminth genomes have taught us about parasite evolution.Parasitology · 2015Pooled it
- The history of Wolbachia and heartworm.Parasites & vectors · 2026Review
- Current issues in heartworm chemotherapy.Parasites & vectors · 2026Review
- Population genomics reveals an ancient origin of heartworms in canids.Communications biology · 2026Article
- Chromosome-contiguous nuclear genome ofOne health (Amsterdam, Netherlands) · 2025Article
- Historical and Projected Impact of Global Climate Change on the Extrinsic Incubation ofEcology and evolution · 2025Article
- Unveiling unique allergenic properties of rapeseed oil: A clinical case study.The journal of allergy and clinical immunology. Global · 2025Article
- Article
- Characterization of a unique catechol-O-methyltransferase as a molecular drug target in parasitic filarial nematodes.PLoS neglected tropical diseases · 2024Article
- First molecular characterization of Dirofilaria Immitis in Cuba.BMC veterinary research · 2023Article
- Phylogenomic Analysis of 155 Helminth Species Reveals Widespread Absence of Oxygen Metabolic Capacity.Genome biology and evolution · 2023Article
- Pangenomic analysis ofFrontiers in microbiology · 2023Article
- Genetic polymorphism, constitutive expression and tissue localization of Dirofilaria immitis P-glycoprotein 11: a putative marker of macrocyclic lactone resistance.Parasites & vectors · 2022Article
- Exploration of the sensitivity to macrocyclic lactones in the canine heartworm (Dirofilaria immitis) in Australia using phenotypic and genotypic approaches.International journal for parasitology. Drugs and drug resistance · 2022Article
- Challenges in Veterinary Vaccine Development.Methods in molecular biology (Clifton, N.J.) · 2022Review
- Genome and proteome screening of Onchocerca volvulus reveal putative vaccine candidates.Molecular biomedicine · 2021Article
- Concern forPathogens (Basel, Switzerland) · 2021Review
- X-treme loss of sequence diversity linked to neo-X chromosomes in filarial nematodes.PLoS neglected tropical diseases · 2021Article
- Heartworm disease - Overview, intervention, and industry perspective.International journal for parasitology. Drugs and drug resistance · 2021Review
- The community-curated Pristionchus pacificus genome facilitates automated gene annotation improvement in related nematodes.BMC genomics · 2021Article
20 more citing papers are in PubMed but not listed here.
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17 authors.
Funding
Abstract
The heartworm Dirofilaria immitis is an important parasite of dogs. Transmitted by mosquitoes in warmer climatic zones, it is spreading across southern Europe and the Americas at an alarming pace. There is no vaccine, and chemotherapy is prone to complications. To learn more about this parasite, we have sequenced the genomes of D. immitis and its endosymbiont Wolbachia. We predict 10,179 protein coding genes in the 84.2 Mb of the nuclear genome, and 823 genes in the 0.9-Mb Wolbachia genome. The D. immitis genome harbors neither DNA transposons nor active retrotransposons, and there is very little genetic variation between two sequenced isolates from Europe and the United States. The differential presence of anabolic pathways such as heme and nucleotide biosynthesis hints at the intricate metabolic interrelationship between the heartworm and Wolbachia. Comparing the proteome of D. immitis with other nematodes and with mammalian hosts, we identify families of potential drug targets, immune modulators, and vaccine candidates. This genome sequence will support the development of new tools against dirofilariasis and aid efforts to combat related human pathogens, the causative agents of lymphatic filariasis and river blindness.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.