Evidence map›Paper›PMID 22889573›Full record

Trial reportAtherosclerosis2012

A randomized trial of exercise for blood pressure reduction in type 2 diabetes: effect on flow-mediated dilation and circulating biomarkers of endothelial function.

Bethany Barone Gibbs, Devon A Dobrosielski, Susanne Bonekamp, Kerry J Stewart, Jeanne M Clark

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Atherosclerosis, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 15 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 15 syntheses or guidelines pooled it, 61 citations in OpenAlex.

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  14. Influence of food patterns on endothelial biomarkers: a systematic review.Journal of clinical hypertension (Greenwich, Conn.) · 2014
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Bethany Barone GibbsDepartment of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. bbarone@pitt.edu
Devon A Dobrosielski
Susanne Bonekamp
Kerry J Stewart
Jeanne M Clark
Johns Hopkins University · US

Funding

Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
Exercise training in type 2 diabetes and hypertensionR01DK062368 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI STEWART, KERRY J. · 2004 to 2008
$2.5M
Cardiovascular and hepatic effects of exercise in hypertensive adultsR21HL095157 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CLARK, JEANNE M · 2009 to 2010
$451k
NCRR NIH HHS UL1 RR 025005NCRR NIH HHS UL1 RR025005NHLBI NIH HHS R21 HL095157NHLBI NIH HHS R21-HL095157NIDDK NIH HHS R01 DK062368NIDDK NIH HHS R01 DK062368-04
6 · The paper itself

Abstract

objectiveTo investigate the effect of an exercise intervention on flow-mediated dilation (FMD) and circulating endothelial biomarkers in adults with type 2 diabetes (T2DM).

methodsSedentary adults (n = 140), aged 40-65, with T2DM and untreated pre or Stage I hypertension or treated hypertension were randomized to a 6-month, supervised, exercise program (3× week) or a sedentary control. Assessments included BMI, body and visceral fat, blood pressure, lipids, HbA1c, insulin sensitivity (QUICKI), fitness, FMD, E-selectin, P-selectin, intracellular and vascular cellular adhesion molecules (ICAM, VCAM), and tissue plasminogen activator (tPA). Intervention effects were compared by t-tests. Pearson's correlations were calculated between changes in cardiovascular risk factors and endothelial outcomes.

resultsExercisers significantly improved BMI (-0.6 kg/m(2)), body fat % (-1.4%), HbA1c (-0.5%), and fitness (2.9 mL/kg min) vs. controls (p < 0.05). However, there were no differences between groups in changes in FMD, E-selectin, P-selectin, ICAM, VCAM, or tPA. Among exercisers, changes in cardiovascular risk factors correlated with several biomarkers. Decreased P-selectin correlated with decreased BMI (r = 0.29, p = 0.04) and increased HDL cholesterol (r = -0.36, p = 0.01). Decreased ICAM correlated with decreased triglycerides and HbA1c (r = 0.30, p = 0.04; r = 0.31, p = 0.03) and increased QUICKI (r = - 0.28, p = 0.05). Decreased tPA correlated with decreased total body and visceral fat (r = 0.28, p = 0.05; r = 0.38, p = 0.008) and increased QUICKI (r = -0.38, p = 0.007).

conclusionsWhile exercise resulted in improved fitness, body composition, and glycemic control, there were no changes in FMD or circulating endothelial biomarkers. The associations of changes in cardiovascular risk factors and endothelial biomarkers suggest that improvement in risk factors could mediate the exercise-induced improvements in endothelial function seen in prior studies.

Indexed as

Blood PressureExercise TherapyVasodilationAdiposityBaltimoreBiomarkersBody Mass IndexDiabetes Mellitus, Type 2Endothelium, VascularE-SelectinFemaleGlycated HemoglobinHumansHypertensionInsulin ResistanceIntercellular Adhesion Molecule-1BiomarkersE-SelectinGlycated Hemoglobinhemoglobin A1c protein, humanIntercellular Adhesion Molecule-1LipidsP-SelectinSELE protein, humanSELP protein, humanTissue Plasminogen ActivatorVascular Cell Adhesion Molecule-1

Identifiers

PMID22889573
PMCPMC3459298
OpenAlexW2044588184

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.