ArticleBMC medicine2012
Implications of stress-induced genetic variation for minimizing multidrug resistance in bacteria.
Article in BMC medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Send more data: a systematic review of mathematical models of antimicrobial resistance.Antimicrobial resistance and infection control · 2018Pooled it
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- Sanitary installations and wastewater plumbing as reservoir for the long-term circulation and transmission of carbapenemase producing Citrobacter freundii clones in a hospital setting.Antimicrobial resistance and infection control · 2023Article
- Comparing optimization criteria in antibiotic allocation protocols.Royal Society open science · 2022Article
- Antibiotic treatment protocols revisited: the challenges of a conclusive assessment by mathematical modelling.Journal of the Royal Society, Interface · 2021Article
- Comparing treatment strategies to reduce antibiotic resistance in an in vitro epidemiological setting.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Using rapid point-of-care tests to inform antibiotic choice to mitigate drug resistance in gonorrhoea.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2020Article
- Mathematical modelling to study the horizontal transfer of antimicrobial resistance genes in bacteria: current state of the field and recommendations.Journal of the Royal Society, Interface · 2019Article
- Adaptive antibacterial biomaterial surfaces and their applications.Materials today. Bio · 2019Review
- Application of dynamic modelling techniques to the problem of antibacterial use and resistance: a scoping review.Epidemiology and infection · 2018Article
- Implant infections: adhesion, biofilm formation and immune evasion.Nature reviews. Microbiology · 2018Review
- Death and population dynamics affect mutation rate estimates and evolvability under stress in bacteria.PLoS biology · 2018Article
- Vaccination can drive an increase in frequencies of antibiotic resistance among nonvaccine serotypes ofProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Modeling antibiotic treatment in hospitals: A systematic approach shows benefits of combination therapy over cycling, mixing, and mono-drug therapies.PLoS computational biology · 2017Article
- Stress-induced mutagenesis: Stress diversity facilitates the persistence of mutator genes.PLoS computational biology · 2017Article
- With a little help from my friends: cooperation can accelerate the rate of adaptive valley crossing.BMC evolutionary biology · 2017Article
- Xerotolerant bacteria: surviving through a dry spell.Nature reviews. Microbiology · 2017Review
- Condition-dependent sex: who does it, when and why?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Does High-Dose Antimicrobial Chemotherapy Prevent the Evolution of Resistance?PLoS computational biology · 2016Article
- Mutation--The Engine of Evolution: Studying Mutation and Its Role in the Evolution of Bacteria.Cold Spring Harbor perspectives in biology · 2015Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAntibiotic resistance in bacterial infections is a growing threat to public health. Recent evidence shows that when exposed to stressful conditions, some bacteria perform higher rates of horizontal gene transfer and mutation, and thus acquire antibiotic resistance more rapidly.
methodsWe incorporate this new notion into a mathematical model for the emergence of antibiotic multi-resistance in a hospital setting.
resultsWe show that when stress has a considerable effect on genetic variation, the emergence of antibiotic resistance is dramatically affected. A strategy in which patients receive a combination of antibiotics (combining) is expected to facilitate the emergence of multi-resistant bacteria when genetic variation is stress-induced. The preference between a strategy in which one of two effective drugs is assigned randomly to each patient (mixing), and a strategy where only one drug is administered for a specific period of time (cycling) is determined by the resistance acquisition mechanisms. We discuss several features of the mechanisms by which stress affects variation and predict the conditions for success of different antibiotic treatment strategies.
conclusionsThese findings should encourage research on the mechanisms of stress-induced genetic variation and establish the importance of incorporating data about these mechanisms when considering antibiotic treatment strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.