Evidence map›Paper›PMID 22888806›Full record

Trial reportJournal of health communication2013

Testing different communication formats on responses to imagined risk of having versus missing the GSTM1 gene.

James A Shepperd, Isaac M Lipkus, Saskia C Sanderson, Colleen M McBride, Suzanne C O'Neill, Sharron Docherty

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of health communication, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

James A ShepperdDepartment of Psychology, University of Florida, Gainesville, Florida 32611, USA. shepperd@ufl.edu
Isaac M Lipkus
Saskia C Sanderson
Colleen M McBride
Suzanne C O'Neill
Sharron Docherty
Duke University · USGeorgetown University · USNational Human Genome Research Institute · USUniversity of Florida · US

Funding

Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI MARCUS S NOEL · 1990 to 2026
$71.5M
Multiplex InitiativeZIAHG200344 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI MC BRIDE, COLLEEN M · 2009 to 2013
$3.9M
Young Smoker's Reactions to Genetic Risk for Lung CancerR01CA121922 · NCI · DUKE UNIVERSITY · PI LIPKUS, ISAAC M · 2007 to 2011
$1.8M
NCI NIH HHS P30 CA051008NCI NIH HHS R01 CA121922NCI NIH HHS R01 CA121922-01A2
6 · The paper itself

Abstract

Genetic markers of lung cancer susceptibility, such as the common variant of the glutathione S-transferase Mu 1 gene (GSTM1-null), confer small probabilities of disease risk. The authors explored the influence of different approaches to communicating the small variations in risk associated with this biomarker. College smokers (N = 128) imagined that they had the GSTM1 wild-type variant versus the GSTM1 null-type variant. The authors presented lung cancer risk in 6 ways that varied the risk format (absolute risk vs. incremental risk) and the presentation style of the information (no graphics vs. graphic display of foreground only vs. graphic display of foreground + background). Presentation style had minor effects. However, absolute risk information increased negative emotions more than did incremental risk information. Perceptions of risk and negative emotions were most profoundly affected by the difference between having the GSTM1 wild-type variant versus the GSTM1 null-type variant. The authors discuss implications for conveying small probabilities related to genetic risk.

Indexed as

Attitude to HealthAdolescentFemaleFloridaGenetic MarkersGenetic Predisposition to DiseaseGlutathione TransferaseHealth CommunicationHumansLung NeoplasmsMaleRisk AssessmentSmokingStudentsUniversitiesYoung AdultGenetic MarkersGlutathione Transferase

Identifiers

PMID22888806
PMCPMC3543503
OpenAlexW2053086162

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.