Evidence map›Paper›PMID 22888434›Full record

ArticleJournal of pregnancy2012

Extrinsic factors influencing fetal deformations and intrauterine growth restriction.

Wendy Moh, John M Graham, Isha Wadhawan, Pedro A Sanchez-Lara

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Journal of pregnancy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02738463 (Role of Maternal Serum Ferritin in the Prediction of Low Neonatal Birth Weight), which is not on this map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
5.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02738463 unknown statusnot on this mapstarted 2016, after this paper: background citation

Role of Maternal Serum Ferritin in the Prediction of Low Neonatal Birth Weight

Typeobservational_patient_registrySponsorAin Shams Maternity HospitalRan2016 to 2016Enrolled64ConditionsIUGR
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 43 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Wendy MohCenter for Craniofacial Molecular Biology, Ostrow School of Dentistry and Children's Hospital Los Angeles, Keck School of Medicine of the University of Southern California, 4650 Sunset Boulevard, MS 90, Los Angeles, CA 90027, USA.
John M Graham
Isha Wadhawan
Pedro A Sanchez-Lara
Cedars-Sinai Medical Center · USChildren's Hospital of Los Angeles · USUniversity of Southern California · US

Funding

TGF BETA SIGNALING AND CRANIOFACIAL MORPHOGENESISR37DE012711 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHAI, YANG · 2009 to 2018
$4.3M
NIDCR NIH HHS R37 DE012711
6 · The paper itself

Abstract

The causes of intrauterine growth restriction (IUGR) are multifactorial with both intrinsic and extrinsic influences. While many studies focus on the intrinsic pathological causes, the possible long-term consequences resulting from extrinsic intrauterine physiological constraints merit additional consideration and further investigation. Infants with IUGR can exhibit early symmetric or late asymmetric growth abnormality patterns depending on the fetal stage of development, of which the latter is most common occurring in 70-80% of growth-restricted infants. Deformation is the consequence of extrinsic biomechanical factors interfering with normal growth, functioning, or positioning of the fetus in utero, typically arising during late gestation. Biomechanical forces play a critical role in the normal morphogenesis of most tissues. The magnitude and direction of force impact the form of the developing fetus, with a specific tissue response depending on its pliability and stage of development. Major uterine constraining factors include primigravida, small maternal size, uterine malformation, uterine fibromata, early pelvic engagement of the fetal head, aberrant fetal position, oligohydramnios, and multifetal gestation. Corrective mechanical forces similar to those that gave rise to the deformation to reshape the deformed structures are often used and should take advantage of the rapid postnatal growth to correct form.

Identifiers

PMID22888434
PMCPMC3409542
OpenAlexW2160599189

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.