Evidence map›Paper›PMID 22888344›Full record

ArticleInternational journal of endocrinology2012

Aging and bone health in individuals with developmental disabilities.

Joan Jasien, Caitlin M Daimon, Stuart Maudsley, Bruce K Shapiro, Bronwen Martin

Open access · goldAbstract read
In one paragraph

Article in International journal of endocrinology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Trial
  4. Intellectual disabilities and risk of fractures: A population-based cohort study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Observational
  10. Canadian family physician Medecin de famille canadien · 2018
    Article
  11. Review
  12. Age-related changes in trabecular and cortical bone microstructure.International journal of endocrinology · 2013
    Article
  13. Adaptation of the lateral distal femur DXA scan technique to adults with disabilities.Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Joan JasienMetabolism Unit, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Suite 100, Baltimore, MD 21224, USA.
Caitlin M Daimon
Stuart Maudsley
Bruce K Shapiro
Bronwen Martin
Kennedy Krieger Institute · USNational Institute on Aging · USNational Institutes of Health · US

Funding

Oxidative stresses and complex proteomic responses to themZIAAG000325 · NIA · NATIONAL INSTITUTE ON AGING · PI MAUDSLEY, STUART · 2009 to 2012
$1.4M
Age and pathology-induced alteration of G protein-coupled receptor signalingZIAAG000318 · NIA · NATIONAL INSTITUTE ON AGING · PI MAUDSLEY, STUART · 2009 to 2012
$1.0M
Innate intelligence and prognostication for prevention of neurodegenerationZIAAG000319 · NIA · NATIONAL INSTITUTE ON AGING · PI MAUDSLEY, STUART · 2009 to 2012
$1.0M
Cognitive function and metabolic controlZIAAG000917 · NIA · NATIONAL INSTITUTE ON AGING · PI MARTIN, BRONWEN · 2010 to 2012
$901k
A systems biology approach for assessing metabolic alterations across life-spanZIAAG000915 · NIA · NATIONAL INSTITUTE ON AGING · PI MARTIN, BRONWEN · 2010 to 2012
$548k
Development of novel methods for systems biology of metabolism and agingZIAAG000916 · NIA · NATIONAL INSTITUTE ON AGING · PI MARTIN, BRONWEN · 2010 to 2012
$518k
6 · The paper itself

Abstract

Low bone mass density (BMD), a classical age-related health issue and a known health concern for fair skinned, thin, postmenopausal Caucasian women, is found to be common among individuals with developmental/intellectual disabilities (D/IDs). It is the consensus that BMD is decreased in both men and women with D/ID. Maintaining good bone health is important for this population as fractures could potentially go undetected in nonverbal individuals, leading to increased morbidity and a further loss of independence. This paper provides a comprehensive overview of bone health of adults with D/ID, their risk of fractures, and how this compares to the general aging population. We will specifically focus on the bone health of two common developmental disabilities, Down syndrome (DS) and cerebral palsy (CP), and will discuss BMD and fracture rates in these complex populations. Gaining a greater understanding of how bone health is affected in individuals with D/ID could lead to better customized treatments for these specific populations.

Identifiers

PMID22888344
PMCPMC3408668
OpenAlexW2164228167

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.