ArticleFrontiers in endocrinology2012
Mechanisms and clinical consequences of vascular calcification.
Article in Frontiers in endocrinology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Statin Use and Coronary Artery Calcification: a Systematic Review and Meta-analysis of Observational Studies and Randomized Controlled Trials.Current atherosclerosis reports · 2023Pooled it
- Trial
- Progress on the related mechanisms of vascular calcification in autogenous arteriovenous fistula in hemodialysis patients.Renal failure · 2026Review
- Article
- Role and mechanism of G9A-BMP2 in calcification-induced formation of unstable plaque.Atherosclerosis plus · 2026Article
- Sclerostin in Vascular Calcification: Hypoxia-Driven Regulation and Therapeutic Modulation by Natural Products.Current atherosclerosis reports · 2026Review
- Reduced Circulating α-Klotho Levels Are Associated With Elevated Mortality and Arterial Calcifications of Aorta and Iliac Arteries.Journal of the American Heart Association · 2025Article
- Article
- Monitoring, Control, and Clinical Outcomes Associated With Chronic Kidney Disease-Mineral Bone Disorder: A Population-Based Cohort Study in Ontario, Canada.Kidney medicine · 2025Article
- The OsteoSense Imaging Agent Identifies Organ-Specific Patterns of Soft Tissue Calcification in an Adenine-Induced Chronic Kidney Disease Mouse Model.International journal of molecular sciences · 2025Article
- Considerations on the Development of Therapeutics in Vascular Calcification.Journal of cardiovascular development and disease · 2025Review
- Exploring Bone Morphogenetic Protein-2 and -4 mRNA Expression and Their Receptor Assessment in a DynamicCells · 2024Article
- The Physiological Functions and Therapeutic Potential of Hypoxia-Inducible Factor-1α in Vascular Calcification.Biomolecules · 2024Review
- Gla-Rich Protein Is Associated with Vascular Calcification, Inflammation, and Mineral Markers in Peritoneal Dialysis Patients.Journal of clinical medicine · 2024Article
- Objective Methods to Assess Aorto-Iliac Calcifications: A Systematic Review.Diagnostics (Basel, Switzerland) · 2024Review
- Vascular Calcification: Molecular Networking, Pathological Implications and Translational Opportunities.Biomolecules · 2024Review
- p53 Regulates Mitochondrial Dynamics in Vascular Smooth Muscle Cell Calcification.International journal of molecular sciences · 2023Article
- The therapeutic potential of sphingolipids for cardiovascular diseases.Frontiers in cardiovascular medicine · 2023Review
- Comparative analysis of calcified soft tissues revealed shared deregulated pathways.Frontiers in aging neuroscience · 2023Article
- Molecular Imaging and Quantification of Smooth Muscle Cell and Aortic Tissue Calcification In Vitro and Ex Vivo with a Fluorescent Hydroxyapatite-Specific Probe.Biomedicines · 2022Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Vascular calcification has severe clinical consequences and is considered an accurate predictor of future adverse cardiovascular events, including myocardial infarction and stroke. Previously vascular calcification was thought to be a passive process which involved the deposition of calcium and phosphate in arteries and cardiac valves. However, recent studies have shown that vascular calcification is a highly regulated, cell-mediated process similar to bone formation. In this article, we outline the current understanding of key mechanisms governing vascular calcification and highlight the clinical consequences. By understanding better the molecular pathways and genetic circuitry responsible for the pathological mineralization process novel drug targets may be identified and exploited to combat and reduce the detrimental effects of vascular calcification on human health.
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