ArticleInternational journal of nanomedicine2012
Prostate stem cell antigen-targeted nanoparticles with dual functional properties: in vivo imaging and cancer chemotherapy.
Article in International journal of nanomedicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Experimental models in immuno-oncology and their translational impact.Discover oncology · 2026Review
- Prostate Stem Cell Antigen-Targeted DNA Aptamer Probe with Ultrahigh Tumor Contrast for Precision Fluorescence-Guided Surgery of Prostate Cancer.Bioconjugate chemistry · 2026Article
- Significance of PSCA as a novel prognostic marker and therapeutic target for cancer.Cancer cell international · 2024Review
- Fabrication of Antibody Conjugated Super Magnetic Oxide Nanoparticles for Early Detection of Prostate Cancer.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Cytotoxicity of targeted PLGA nanoparticles: a systematic review.RSC advances · 2021Review
- ENO1-targeted superparamagnetic iron oxide nanoparticles for detecting pancreatic cancer by magnetic resonance imaging.Journal of cellular and molecular medicine · 2020Article
- Targeted Radionuclide Therapy of Prostate Cancer-From Basic Research to Clinical Perspectives.Molecules (Basel, Switzerland) · 2020Review
- Aptamer-Conjugated Multifunctional Polymeric Nanoparticles as Cancer-Targeted, MRI-Ultrasensitive Drug Delivery Systems for Treatment of Castration-Resistant Prostate Cancer.BioMed research international · 2020Article
- In-vitro prostate cancer biomarker detection by directed conjugation of anti-PSCA antibody to super paramagnetic iron oxide nanoparticless.Medical journal of the Islamic Republic of Iran · 2019Article
- Dendrimer- and copolymer-based nanoparticles for magnetic resonance cancer theranostics.Theranostics · 2018Review
- Magnetic nanoformulations for prostate cancer.Drug discovery today · 2017Review
- Molecular imaging of prostate cancer: translating molecular biology approaches into the clinical realm.European radiology · 2015Review
- Cancer active targeting by nanoparticles: a comprehensive review of literature.Journal of cancer research and clinical oncology · 2015Review
- Cardiotoxicity due to chemotherapy: role of cardiac imaging.Current cardiology reports · 2015Review
- Nanoparticle mediated chemotherapy of hormone refractory prostate cancer with a novel combi-molecule.American journal of translational research · 2015Article
- Diagnosis of prostate cancer via nanotechnological approach.International journal of nanomedicine · 2015Review
- Prostate cancer relevant antigens and enzymes for targeted drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2014Review
- Can nanomedicines kill cancer stem cells?Advanced drug delivery reviews · 2013Review
- Prostate cancer research in China.Asian journal of andrology · 2013Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe designed dual-functional nanoparticles for in vivo application using a modified electrostatic and covalent layer-by-layer assembly strategy to address the challenge of assessment and treatment of hormone-refractory prostate cancer.
methodsCore-shell nanoparticles were formulated by integrating three distinct functional components, ie, a core constituted by poly(D,L-lactic-co-glycolic acid), docetaxel, and hydrophobic superparamagnetic iron oxide nanocrystals (SPIONs), a multilayer shell formed by poly(allylamine hydrochloride) and two different sized poly(ethylene glycol) molecules, and a single-chain prostate stem cell antigen antibody conjugated to the nanoparticle surface for targeted delivery.
resultsDrug release profiles indicated that the dual-function nanoparticles had a sustained release pattern over 764 hours, and SPIONs could facilitate the controlled release of the drug in vitro. The nanoparticles showed increased antitumor efficiency and enhanced magnetic resonance imaging in vitro through targeted delivery of docetaxel and SPIONs to PC3M cells. Moreover, in nude mice bearing PC3M xenografts, the nanoparticles provided MRI negative contrast enhancement, as well as halting and even reversing tumor growth during the 76-day study duration, and without significant systemic toxicity. The lifespan of the mice treated with these targeted dual-function nanoparticles was significantly increased (Chi-square = 22.514, P < 0.0001).
conclusionThis dual-function nanomedical platform may be a promising candidate for tumor imaging and targeted delivery of chemotherapeutic agents in vivo.
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