ArticleJournal of biomedicine & biotechnology2012
Biomarkers of adverse response to mercury: histopathology versus thioredoxin reductase activity.
Article in Journal of biomedicine & biotechnology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 34 citations in OpenAlex.
- Selenium and Redox Enzyme Activity in Pregnant Women Exposed to Methylmercury.Antioxidants (Basel, Switzerland) · 2022Article
- Mercury interactions with selenium and sulfur and the relevance of the Se:Hg molar ratio to fish consumption advice.Environmental science and pollution research international · 2021Article
- Bioremediation byMicroorganisms · 2020Article
- The Putative Role of Environmental Mercury in the Pathogenesis and Pathophysiology of Autism Spectrum Disorders and Subtypes.Molecular neurobiology · 2018Review
- The role of the thioredoxin/thioredoxin reductase system in the metabolic syndrome: towards a possible prognostic marker?Cellular and molecular life sciences : CMLS · 2018Review
- Toxicodynamics of Lead, Cadmium, Mercury and Arsenic- induced kidney toxicity and treatment strategy: A mini review.Toxicology reports · 2018Review
- Neurodevelopmental Effects of Mercury.Advances in neurotoxicology · 2018Article
- Effect of thimerosal on thyroid hormones metabolism in rats.Endocrine connections · 2017Article
- The catecholaminergic neurotransmitter system in methylmercury-induced neurotoxicity.Advances in neurotoxicology · 2017Article
- Possible Mechanisms of Mercury Toxicity and Cancer Promotion: Involvement of Gap Junction Intercellular Communications and Inflammatory Cytokines.Oxidative medicine and cellular longevity · 2017Review
- Biomarkers of mercury toxicity: Past, present, and future trends.Journal of toxicology and environmental health. Part B, Critical reviews · 2017Review
- Sex- and structure-specific differences in antioxidant responses to methylmercury during early development.Neurotoxicology · 2016Article
- Multiple classes of environmental chemicals are associated with liver disease: NHANES 2003-2004.International journal of hygiene and environmental health · 2013Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exposure to mercury is normally assessed by measuring its accumulation in hair, blood or urine. Currently, the biomarkers of effect that have been proposed for mercurials, such as coproporphyrines or oxidative stress markers, are not sensitive enough and lack specificity. Selenium and selenoproteins are important targets for mercury and thioredoxin reductase (TrxR) in particular was shown to be very sensitive to mercury compounds both in vitro and in vivo. In this study we looked into the relation between the inhibition of thioredoxin reductase (TrxR) activity and histopathological changes caused by exposure to mercurials. Juvenile zeabra-seabreams were exposed to Hg(2+) or MeHg for 28 days and histopathological changes were analyzed in the liver and kidney as well as TrxR activity. Both mercurials caused histopathological changes in liver and kidney, albeit Hg(2+) caused more extensive and severe lesions. Likewise, both mercurials decreased TrxR activity, being Hg(2+) a stronger inhibitor. Co-exposure to Hg(2+) and Se fully prevented TrxR inhibition in the liver and reduced the severity of lesions in the organ. These results show that upon exposure to mercurials, histopathological alterations correlate with the level of TrxR activity and point to the potential use of this enzyme as a biomarker of mercury toxicity.
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