ArticlePhytotherapy research : PTR2013
High throughput screening to identify natural human monoamine oxidase B inhibitors.
Article in Phytotherapy research : PTR, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- Traditional Uses, Phytochemistry, and Multi-Target Pharmacological Activities of Senna alexandrina.Chemistry & biodiversity · 2026Review
- Multifunctional Therapeutic Potential of Phytocomplexes fromMini reviews in medicinal chemistry · 2026Review
- Isolation, Characterization, In Vitro and In Silico Assessment of Undescribed Bioactive Constituents fromACS omega · 2024Article
- Synthesis of Novel Plant-Derived Encapsulated Radiolabeled Compounds for the Diagnosis of Parkinson's Disease and the Evaluation of Biological Effects with In Vitro/In Vivo Methods.Molecular neurobiology · 2024Article
- Review
- The neuroprotective effect of traditional Chinese medicinal plants-A critical review.Acta pharmaceutica Sinica. B · 2023Review
- Evidence for anti-inflammatory effects and modulation of neurotransmitter metabolism by Salvia officinalis L.BMC complementary medicine and therapies · 2022Article
- Inhibition of Human Monoamine Oxidases A and B by Specialized Metabolites Present in Fresh Common Fruits and Vegetables.Plants (Basel, Switzerland) · 2022Article
- Review
- Antioxidant-Rich Fraction of Urtica dioica Mediated Rescue of Striatal Mito-Oxidative Damage in MPTP-Induced Behavioral, Cellular, and Neurochemical Alterations in Rats.Molecular neurobiology · 2017Article
- The Benzopyrone Biochanin-A as a reversible, competitive, and selective monoamine oxidase B inhibitor.BMC complementary and alternative medicine · 2017Article
- Natural Products Screening for the Identification of Selective Monoamine Oxidase-B Inhibitors.European journal of medicinal plants · 2016Article
- Glycyrrhizic acid Attenuates Neuroinflammation and Oxidative Stress in Rotenone Model of Parkinson's Disease.Neurotoxicity research · 2016Article
- Inhibition of Monoamine Oxidase by Stilbenes from Rheum palmatum.Iranian journal of pharmaceutical research : IJPR · 2016Article
- Establishment of a comprehensive list of candidate antiaging medicinal herb used in korean medicine by text mining of the classical korean medical literature, "dongeuibogam," and preliminary evaluation of the antiaging effects of these herbs.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Evaluation of the Inhibitory Effects of Bavachinin and Bavachin on Human Monoamine Oxidases A and B.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Rubus fruticosus L.: constituents, biological activities and health related uses.Molecules (Basel, Switzerland) · 2014Review
- High-Throughput Screening to Identify Plant Derived Human LDH-A Inhibitors.European journal of medicinal plants · 2013Article
- Effects of aqueous extract ofAvicenna journal of phytomedicineArticle
- In vitro Antioxidant and Enzymatic Approaches to Evaluate Neuroprotector Potential of Blechnum Extracts without Cytotoxicity to Human Stem Cells.Pharmacognosy magazineArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Age-related increase in monoamine oxidase B (MAO-B) may contribute to CNS neurodegenerative diseases. Moreover, MAO-B inhibitors are used in the treatment of idiopathic Parkinson disease as preliminary monotherapy or adjunct therapy with L-dopa. To date, meager natural sources of MAO-B inhibitors have been identified, and the relative strength, potency and rank of many plants relative to standard drugs such as Selegiline (L-deprenyl,Eldepryl) are not known. In this work, we developed and utilized a high throughput enzyme microarray format to screen and evaluate 905 natural product extracts (0.025-.7 mg/ml) to inhibit human MAO-B derived from BTI-TN-5B1-4 cells infected with recombinant baculovirus. The protein sequence of purified enzyme was confirmed using 1D gel electrophoresis-matrix assisted laser desorption ionization -time-of-flight-tandem mass spectroscopy, and enzyme activity was confirmed by [1] substrate conversion (3-mM benzylamine) to H202 and [2] benzaldehyde. Of the 905 natural extracts tested, the lowest IC50s [<0.07 mg/ml] were obtained with extracts of Amur Corktree (Phellodendron amurense), Bakuchi Seed(Cyamopsis psoralioides), Licorice Root (Glycyrrhiza glabra/uralensis), Babchi (Psoralea corylifolia seed). The data also show, albeit to a lesser extent, inhibitory properties of herbs originating from the mint family (Lamiaceae) and Turmeric, Comfrey, Bringraj, Skullcap, Kava-kava, Wild Indigo, Gentian and Green Tea. In conclusion, the data reflect relative potency information by rank of commonly used herbs and plants that contain human MAO-B inhibitory properties in their natural form.
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Registered trials
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