Evidence map›Paper›PMID 22887437›Full record

ArticleAngewandte Chemie (International ed. in English)2012

Phosphatase-triggered fusogenic liposomes for cytoplasmic delivery of cell-impermeable compounds.

J P Michael Motion, Juliane Nguyen, Francis C Szoka

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Current status ofRSC advances · 2023
    Review
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

J P Michael MotionUniversity of California, Berkeley, Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94143-0912, USA.
Juliane Nguyen
Francis C Szoka
University of California, Berkeley · USUniversity of California, San Francisco · US

Funding

Maximizing Opportunities for Research Excellence - Evaluation Training SupplementR25GM056847 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUNCAN, D'ANNE S., SELLO, JASON K · 1998 to 2023
$14.1M
Rational Design of Viral-Mimetic Lipid Gene VectorsR01EB003008 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SZOKA, FRANCIS C. · 2003 to 2013
$3.2M
NIBIB NIH HHS R01 EB003008NIGMS NIH HHS R01GM003008NIGMS NIH HHS R25 GM056847NIGMS NIH HHS R25-GM56847
6 · The paper itself

Abstract

License to fuse! A phosphorylated fusion peptide can mediate membrane fusion when the phosphates (green triangles, see scheme) are removed by phosphatases (blue spheres), delivering the contents of the liposome into the cytosol. This phosphatase-triggered approach may be useful to create target-specific lipid nanocarriers.

Indexed as

AnimalsCell Line, TumorCell SurvivalCytoplasmHIV Envelope Protein gp41HumansLiposomesMicePeptidesPhosphoric Monoester HydrolasesTransfectionHIV Envelope Protein gp41LiposomesPeptidesPhosphoric Monoester Hydrolases

Identifiers

PMID22887437
PMCPMC3470804
OpenAlexW2103898841

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.