ArticleSurgery today2013
Management of postoperative hemorrhage associated with factor VIII inhibitor: report of a case.
Article in Surgery today, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Rituximab for eradicating inhibitors in people with acquired haemophilia A.The Cochrane database of systematic reviews · 2021Pooled it
- Rituximab for eradicating inhibitors in people with acquired haemophilia A.The Cochrane database of systematic reviews · 2016Pooled it
- Acquired hemophilia A secondary to cholangiocarcinoma: A case report and literature review.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Review
- Acquired hemophilia A developing in the perioperative period of pancreatoduodenectomy: a report of two cases.Surgical case reports · 2023Article
- Repeated bleeding caused by acquired hemophilia A after endoscopic submucosal dissection: A case report and literature review.Experimental and therapeutic medicine · 2023Article
- Recurrent bleeding after rubber band ligation diagnosed as mild hemophilia B: a case report and literature review.BMC surgery · 2022Review
- Acquired haemophilia in patients with malignant disease: A case report.World journal of clinical cases · 2021Article
- Surgery-associated acquired hemophilia A: a report of 2 cases and review of literature.BMC surgery · 2020Review
- "The Immune Conundrum": Acquired Hemophilia A, Immune Thrombocytopenia, and Neutropenia in a Patient with Pancreatic Cancer.Case reports in pancreatic cancer · 2016Article
- A case of acquired hemophilia A diagnosed after percutaneous endoscopic gastrostomy.Clinical journal of gastroenterology · 2015Article
- Acquired hemophilia A as a cause of recurrent bleeding into the pleural cavity - case report and literature review.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2014Article
- Severe postoperative hemorrhage caused by antibody-mediated coagulation factor deficiencies: report of two cases.Surgery today · 2014Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This report presents a case that was successfully treated for acquired factor VIII inhibitor after extensive visceral surgery. A 71-year-old male who underwent surgery for bile duct cancer had active bleeding in the abdominal drainage tube on postoperative day (POD) 5, and prolonged activated partial thromboplastin time (aPTT) was detected (83.1 s) on POD 7. An extensive coagulation work-up revealed factor VIII deficiency (1 %), and a diagnosis of an acquired factor VIII deficiency was established when a factor VIII inhibitor of 8 Bethesda units was demonstrated. The patient was treated with activated prothrombin complex concentrate (aPCCs) and bloody discharge was stopped within 3 days. Inhibitor elimination was started using prednisolone on POD 20; rituximab, was administered on POD 74 and 81. Factor VIII inhibitor had disappeared by POD 124, and factor VIII (72 %) and aPTT recovered to 45.9 s. This case report demonstrated the efficacy of aPCCs and rituximab in the treatment of acquired hemophilia associated with visceral surgery.
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Registered trials
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