ArticleBiomechanics and modeling in mechanobiology2013
Empirical measurements of biomechanical anisotropy of the human vocal fold lamina propria.
Article in Biomechanics and modeling in mechanobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Regenerative Strategies for Vocal Fold Repair Using Injectable Materials.Biomimetics (Basel, Switzerland) · 2025Review
- A fibril-scale visco-hyperelastic model for the mechanics of vocal-fold tissues.Frontiers in bioengineering and biotechnology · 2025Article
- Article
- Flow-induced oscillations of vocal-fold replicas with tuned extensibility and material properties.Scientific reports · 2023Article
- The Influence of Fiber Orientation of the Conus Elasticus in Vocal Fold Modeling.Journal of biomechanical engineering · 2023Article
- Shrinkage of specimens after COEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Article
- Nonlinear viscoelastic characterization of human vocal fold tissues under large-amplitude oscillatory shear (LAOS).Journal of rheology · 2018Article
- Biaxial mechanical properties of human vocal fold cover under vocal fold elongation.The Journal of the Acoustical Society of America · 2017Article
- Comparison of a fiber-gel finite element model of vocal fold vibration to a transversely isotropic stiffness model.The Journal of the Acoustical Society of America · 2017Article
- Mechanics of human voice production and control.The Journal of the Acoustical Society of America · 2016Article
- Functional assessment of the ex vivo vocal folds through biomechanical testing: A review.Materials science & engineering. C, Materials for biological applications · 2016Review
- THE ROLE OF THE THYROARYTENOID MUSCLE IN REGULATING GLOTTAL AIRFLOW AND GLOTTAL CLOSURE IN AN IN VIVO CANINE LARYNX MODEL.Proceedings of meetings on acoustics. Acoustical Society of America · 2014Article
- Validation of a flow-structure-interaction computation model of phonation.Journal of fluids and structures · 2014Article
- Indentation of poroviscoelastic vocal fold tissue using an atomic force microscope.Journal of the mechanical behavior of biomedical materials · 2013Article
- The anisotropic nature of the human vocal fold: an ex vivo study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2013Article
- The anisotropic hyperelastic biomechanical response of the vocal ligament and implications for frequency regulation: a case study.The Journal of the Acoustical Society of America · 2013Article
- Development and validation of a 3D laryngeal model in surgical skills training.Brazilian journal of otorhinolaryngologyArticle
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The vocal folds are known to be mechanically anisotropic due to the microstructural arrangement of fibrous proteins such as collagen and elastin in the lamina propria. Even though this has been known for many years, the biomechanical anisotropic properties have rarely been experimentally studied. We propose that an indentation procedure can be used with uniaxial tension in order to obtain an estimate of the biomechanical anisotropy within a single specimen. Experiments were performed on the lamina propria of three male and three female human vocal folds dissected from excised larynges. Two experiments were conducted: each specimen was subjected to cyclic uniaxial tensile loading in the longitudinal (i.e., anterior-posterior) direction, and then to cyclic indentation loading in the transverse (i.e., medial-lateral) direction. The indentation experiment was modeled as contact on a transversely isotropic half-space using the Barnett-Lothe tensors. The longitudinal elastic modulus E(L) was computed from the tensile test, and the transverse elastic modulus E(T) and longitudinal shear modulus G(L) were obtained by inverse analysis of the indentation force-displacement response. It was discovered that the average of E(L) /E(T) was 14 for the vocal ligament and 39 for the vocal fold cover specimens. Also, the average of E(L)/G(L), a parameter important for models of phonation, was 28 for the vocal ligament and 54 for the vocal fold cover specimens. These measurements of anisotropy could contribute to more accurate models of fundamental frequency regulation and provide potentially better insights into the mechanics of vocal fold vibration.
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