ArticleTopics in current chemistry2013
Calculation of hydrodynamic properties for G-quadruplex nucleic acid structures from in silico bead models.
Article in Topics in current chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- DNA-based assay for calorimetric determination of protein concentrations in pure or mixed solutions.PloS one · 2024Article
- Calorimetric analysis using DNA thermal stability to determine protein concentration.bioRxiv : the preprint server for biology · 2023Article
- Long promoter sequences form higher-order G-quadruplexes: an integrative structural biology study of c-Myc, k-Ras and c-Kit promoter sequences.Nucleic acids research · 2022Article
- The solution structures of higher-order human telomere G-quadruplex multimers.Nucleic acids research · 2021Article
- The hTERT core promoter forms three parallel G-quadruplexes.Nucleic acids research · 2020Article
- Predicting Site-Binding Modes of Ions and Water to Nucleic Acids Using Molecular Solvation Theory.Journal of the American Chemical Society · 2019Article
- Structure of human telomere G-quadruplex in the presence of a model drug along the thermal unfolding pathway.Nucleic acids research · 2018Article
- Structure and hydrodynamics of a DNA G-quadruplex with a cytosine bulge.Nucleic acids research · 2018Article
- In What Ways Do Synthetic Nucleotides and Natural Base Lesions Alter the Structural Stability of G-Quadruplex Nucleic Acids?Journal of nucleic acids · 2017Review
- Separation of Quadruplex Polymorphism in DNA Sequences by Reversed-Phase Chromatography.Current protocols in nucleic acid chemistry · 2015Article
- Hydrodynamic Models of G-Quadruplex Structures.Methods in enzymology · 2015Article
- An improved model for the hTERT promoter quadruplex.PloS one · 2014Article
- Thermodynamic characterization of human telomere quadruplex unfolding.Biopolymers · 2013Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Nucleic acids enriched in guanine bases can adopt unique quadruple helical tertiary structures known as G-quadruplexes. G-quadruplexes have emerged as attractive drug targets as many G-quadruplex-forming sequences have been discovered in functionally critical sites within the human genome, including the telomere, oncogene promoters, and mRNA processing sites. A single G-quadruplex-forming sequence can adopt one of many folding topologies, often resulting in a lack of a single definitive atomic-level resolution structure for many of these sequences and a major challenge to the discovery of G-quadruplex-selective small molecule drugs. Low-resolution techniques employed to study G-quadruplex structures (e.g., CD spectroscopy) are often unable to discern between G-quadruplex structural ensembles, while high-resolution techniques (e.g., NMR spectroscopy) can be overwhelmed by a highly polymorphic system. Hydrodynamic bead modeling is an approach to studying G-quadruplex structures that could bridge the gap between low-resolution techniques and high-resolution molecular models. Here, we present a discussion of hydrodynamic bead modeling in the context of studying G-quadruplex structures, highlighting recent successes and limitations to this approach, as well as an example featuring a G-quadruplex structure formed from the human telomere. This example can easily be adapted to the investigation of any other G-quadruplex-forming sequences.
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