Evidence map›Paper›PMID 22886542›Full record

ReviewCurrent topics in microbiology and immunology2013

Studying Salmonellae and Yersiniae host-pathogen interactions using integrated 'omics and modeling.

Charles Ansong, Brooke L Deatherage, Daniel Hyduke, Brian Schmidt, Jason E McDermott, Marcus B Jones, Sadhana Chauhan, Pep Charusanti, Young-Mo Kim, Ernesto S Nakayasu and 12 more

Abstract readReview
In one paragraph

Review in Current topics in microbiology and immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Charles AnsongBiological Separations and Mass Spectroscopy Group, Pacific Northwest National Laboratory, PO Box 999, MSIN: K8-98, Richland, WA, 99352, USA.
Brooke L Deatherage
Daniel Hyduke
Brian Schmidt
Jason E McDermott
Marcus B Jones
Sadhana Chauhan
Pep Charusanti
Young-Mo Kim
Ernesto S Nakayasu
Jie Li
Afshan Kidwai
George Niemann
Roslyn N Brown
Thomas O Metz
Kathleen McAteer
Fred Heffron
Scott N Peterson
Vladimir Motin
Bernhard O Palsson
Richard D Smith
Joshua N Adkins

Funding

WORKSHOP AND TRAINING ACTIVITIESP41RR018522 · NCRR · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI SMITH, RICHARD D · 2003 to 2011
$25.1M
Equipment Supplement Request for a Research Resource for Ultra-sensitive High Throughput ProteomicsP41GM103493 · NIGMS · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI SMITH, RICHARD D · 2012 to 2022
$22.6M
SALMONELLA GENES REQUIRED FOR SURVIVAL IN THE MACROPHAGER01AI022933 · NIAID · SCRIPPS RESEARCH INSTITUTE · PI HEFFRON, FRED L · 1987 to 2013
$4.6M
SURFACE CHEMISTRY OF MYCOBACTERIAR01AI008401 · NIAID · NATIONAL JEWISH HEALTH · PI GOREN, MAYER B. · 1989 to 1989
–
SURFACE CHEMISTRY OF MYCOBACTERIAR22AI008401 · NIAID · NATIONAL JEWISH HEALTH · PI GOREN, MAYER B. · 1985 to 1989
–
NCRR NIH HHS P41 RR018522NIAID NIH HHS R01 AI022933NIAID NIH HHS Y01 AI008401NIGMS NIH HHS P41 GM103493
6 · The paper itself

Abstract

Salmonella and Yersinia are two distantly related genera containing species with wide host-range specificity and pathogenic capacity. The metabolic complexity of these organisms facilitates robust lifestyles both outside of and within animal hosts. Using a pathogen-centric systems biology approach, we are combining a multi-omics (transcriptomics, proteomics, metabolomics) strategy to define properties of these pathogens under a variety of conditions including those that mimic the environments encountered during pathogenesis. These high-dimensional omics datasets are being integrated in selected ways to improve genome annotations, discover novel virulence-related factors, and model growth under infectious states. We will review the evolving technological approaches toward understanding complex microbial life through multi-omic measurements and integration, while highlighting some of our most recent successes in this area.

Indexed as

Host-Pathogen InteractionsAnimalsGenomicsHumansMetabolomicsProteomicsSalmonellaSystems BiologyYersinia

Identifiers

PMID22886542
PMCPMC6197062

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.