ArticleAmerican journal of physiology. Lung cellular and molecular physiology2012
Neuronal Wiskott-Aldrich syndrome protein (N-WASP) is critical for formation of α-smooth muscle actin filaments during myofibroblast differentiation.
Article in American journal of physiology. Lung cellular and molecular physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
- S100A4 Orchestrates Fibroblast Fate to Drive Fibrotic Remodeling.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- ARP2/3 complex affects myofibroblast differentiation and migration in pancreatic ductal adenocarcinoma.International journal of cancer · 2025Article
- The role of the cytoskeleton in fibrotic diseases.Frontiers in cell and developmental biology · 2024Review
- Effects of vitamin D signaling in cardiovascular disease: centrality of macrophage polarization.Frontiers in cardiovascular medicine · 2024Article
- Tuftelin1 drives experimental pulmonary fibrosis progression by facilitating stress fiber assembly.Respiratory research · 2023Article
- A scalable 3D tissue culture pipeline to enable functional therapeutic screening for pulmonary fibrosis.APL bioengineering · 2021Article
- A novel tree shrew model of pulmonary fibrosis.Laboratory investigation; a journal of technical methods and pathology · 2021Article
- Dynein-mediated nuclear translocation of yes-associated protein through microtubule acetylation controls fibroblast activation.Cellular and molecular life sciences : CMLS · 2020Article
- Neuronal Wiskott-Aldrich syndrome protein regulates Pseudomonas aeruginosa-induced lung vascular permeability through the modulation of actin cytoskeletal dynamics.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- MYH9 Inhibition Suppresses TGF-β1-Stimulated Lung Fibroblast-to-Myofibroblast Differentiation.Frontiers in pharmacology · 2020Article
- Molecular mechanism of tumour necrosis factor alpha regulates hypocretin (orexin) expression, sleep and behaviour.Journal of cellular and molecular medicine · 2019Article
- Focal Adhesion Kinase Regulates Hepatic Stellate Cell Activation and Liver Fibrosis.Scientific reports · 2017Article
- Focal adhesion kinase signaling determines the fate of lung epithelial cells in response to TGF-β.American journal of physiology. Lung cellular and molecular physiology · 2017Article
- Conditional knockout of N-WASP in mouse fibroblast caused keratinocyte hyper proliferation and enhanced wound closure.Scientific reports · 2016Article
- Neuronal Wiskott-Aldrich syndrome protein regulates TGF-β1-mediated lung vascular permeability.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
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- S100A4 promotes pancreatic cancer progression through a dual signaling pathway mediated by Src and focal adhesion kinase.Scientific reports · 2015Article
- Ezrin Regulating the Cytoskeleton Remodeling is Required for Hypoxia-Induced Myofibroblast Proliferation and Migration.Frontiers in cardiovascular medicine · 2015Article
- A critical review of the American Journal of Physiology-Lung Cellular and Molecular Physiology: 2012-2015.American journal of physiology. Lung cellular and molecular physiology · 2014Review
- Therapeutic targeting of SRC kinase in myofibroblast differentiation and pulmonary fibrosis.The Journal of pharmacology and experimental therapeutics · 2014Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
Myofibroblasts are implicated in pathological stromal responses associated with lung fibrosis. One prominent phenotypic marker of fully differentiated myofibroblasts is the polymerized, thick cytoplasmic filaments containing newly synthesized α-smooth muscle actin (α-SMA). These α-SMA-containing cytoplasmic filaments are important for myofibroblast contractility during tissue remodeling. However, the molecular mechanisms regulating the formation and maturation of α-SMA-containing filaments have not been defined. This study demonstrates a critical role for neuronal Wiskott-Aldrich syndrome protein (N-WASP) in regulating the formation of α-SMA-containing cytoplasmic filaments during myofibroblast differentiation and in myofibroblast contractility. Focal adhesion kinase (FAK) is activated by transforming growth factor-β1 (TGF-β1) and is required for phosphorylation of tyrosine residue 256 (Y256) of N-WASP. Phosphorylation of Y256 of N-WASP is essential for TGF-β1-induced formation of α-SMA-containing cytoplasmic filaments in primary human lung fibroblasts. In addition, we demonstrate that actin-related protein (Arp) 2/3 complex is downstream of N-WASP and mediates the maturation of α-SMA-containing cytoplasmic filaments. Together, this study supports a critical role of N-WASP in integrating FAK and Arp2/3 signaling to mediate formation of α-SMA-containing cytoplasmic filaments during myofibroblast differentiation and maturation.
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