ReviewInflammation2013
Is the IL-10 promoter polymorphism at position -592 associated with immune system-related diseases?
Review in Inflammation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Association between interleukin-10 gene polymorphisms and multiple sclerosis susceptibility: evidence from a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Pooled it
- Development of a laboratory-based nomogram for predicting clinical outcomes in patients with severe COVID-19 undergoing glucocorticoid therapy.Frontiers in medicine · 2025Article
- Targeting STAT3 signaling pathway by curcumin and its analogues for breast cancer: A narrative review.Animal models and experimental medicine · 2024Review
- The Impact of the IL-10 Gene Polymorphism on mRNA Expression and IL-10 Serum Concentration in Polish Lupus Patients.International journal of molecular sciences · 2024Article
- Association between IL-10 (at position -592) and IL-4 (at position -589) genotype polymorphism with atopic and non-atopic asthma in children.American journal of clinical and experimental immunology · 2023Article
- Interleukin 6 and 10 Serum Levels and Genetic Polymorphisms in Children with Down Syndrome.Mediators of inflammation · 2018Article
- Significant roles played by interleukin-10 in outcome of pregnancy.Iranian journal of basic medical sciences · 2016Review
- Is the polymorphism at position -1082 of IL-10 gene associated with visceral leishmaniasis?Iranian journal of public health · 2014Article
- Significant roles played by IL-10 in Chlamydia infections.Inflammation · 2014Review
- Polymorphisms of tumor necrosis factor-α, transforming growth factor-β, and interleukin-10 in asthma associated with olive pollen sensitization.Journal of immunology research · 2014Article
- Is the IL-10 -819 polymorphism associated with visceral leishmaniasis?Inflammation · 2013Article
- Biomarkers in Multiple Sclerosis: An Up-to-Date Overview.Multiple sclerosis international · 2013Article
- Kidney-targeted transplantation of mesenchymal stem cells by ultrasound-targeted microbubble destruction promotes kidney repair in diabetic nephropathy rats.BioMed research international · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immune responses are the main causes of immune system-related diseases such as hypersensitivities and autoimmunity. It has also been established that cytokines play key roles in the regulation of immune responses which have been shown to be important in the pathogenesis of the diseases. IL-10, the main anti-inflammatory cytokine, is produced by several immune cells such as T regulatory and Th2 lymphocytes, activated macrophages, B regulatory lymphocytes as well as other cell types. It plays a key role in the regulation of immune responses after microbe elimination (homeostasis) and against self-antigens to prevent hypersensitivity and autoimmune diseases, respectively. Studies showed that a single nucleotide polymorphism (SNP) at the -592 position of IL-10 is associated with its regulation of expression. This review addresses the recent information regarding the association of the polymorphism at position -592 of IL-10 with immune-related diseases including type 2 diabetes with and without nephropathy, multiple sclerosis, and asthma with an emphasize on Iranian patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.