SynthesisJournal of neurology2013
Treatment of essential tremor: a systematic review of evidence and recommendations from the Italian Movement Disorders Association.
Synthesis in Journal of neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT02491554 (Deep braIn Stimulation for Tremor TractographIC Versus Traditional), which is not on this map. Cited by 43 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Deep braIn Stimulation for Tremor TractographIC Versus Traditional
Who cites it
43 citing papers in PubMed, 6 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Pooled it
- Magnetic Resonance-Guided Focused Ultrasound Neurosurgery for Essential Tremor: A Health Technology Assessment.Ontario health technology assessment series · 2018Pooled it
- Zonisamide for essential tremor.The Cochrane database of systematic reviews · 2017Pooled it
- Topiramate for essential tremor.The Cochrane database of systematic reviews · 2017Pooled it
- Pregabalin for essential tremor.The Cochrane database of systematic reviews · 2016Pooled it
- Alprazolam for essential tremor.The Cochrane database of systematic reviews · 2015Pooled it
- Dual-target VIM-PSA deep brain stimulation using octopolar electrodes: surgical technique and feasibility study.Frontiers in neurology · 2026Trial
- Cerebellar repetitive transcranial magnetic stimulation versus propranolol for essential tremor.Brain and behavior · 2023Trial
- Differential effects of propranolol on head and upper limb tremor in patients with essential tremor and dystonia.Journal of neurology · 2018Trial
- Anesthesia Management for High-Intensity Focused Ultrasound (HIFU) Thalamotomy for Movement Disorders: A Case Series from the National University Hospital of the Philippines.Acta medica Philippina · 2025Article
- The impact of pregabalin and gabapentin on essential tremor: a systematic review and meta-analysis.Clinical parkinsonism & related disorders · 2025Review
- Treatment for essential tremor: a systematic review and Bayesian Model-based Network Meta-analysis of RCTs.EClinicalMedicine · 2024Article
- Treatment patterns in essential tremor: Real-world evidence from a United Kingdom and France primary care database.European journal of neurology · 2024Article
- Clinical and Economic Correlates of Pharmacotherapy in Patients with Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Article
- Deep brain stimulation for essential tremor in patients with ventriculomegaly.Surgical neurology international · 2024Article
- Effect of Propranolol on Motor Cortex Excitability in Essential Tremor: An Exploratory Study.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Article
- Gabapentinoid Prescribing Practices at a Large Academic Medical Center.Mayo Clinic proceedings. Innovations, quality & outcomes · 2023Article
- Gut microbiota from essential tremor patients aggravates tremors in mice.Frontiers in microbiology · 2023Article
- Neuropsychological assessment protocol in an ongoing randomized controlled trial on posterior subthalamic area vs. ventral intermediate nucleus deep brain stimulation for essential tremor.Frontiers in neurology · 2023Article
- Using Deep Learning for Task and Tremor Type Classification in People with Parkinson's Disease.Sensors (Basel, Switzerland) · 2022Article
Corrections and comments
- Erratum issuedAbbruzzese, Giovanni [added]; Berardelli, Alfredo [added]; Allegra, Roberta [added]; Aniello, Maria Stella [added]; Elia, Antonio E [added]; Martino, Davide [added]; Murgia, Daniela [added]; Picillo, Marina [added]; Squintani, Giovanna [added]
Authors and funding
17 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Essential tremor (ET) is one of the most common movement disorders of adults, characterized by postural and kinetic tremor. It often causes embarrassment and more rarely serious disability, requiring treatment. To assess the current state of knowledge on ET therapy and produce recommendations based on the analysis of evidence the authors reviewed the literature regarding pharmacologic and surgical therapies, providing a quality assessment of the studies and the strength of recommendations for each treatment. A committee of experts selected clinical-based questions to guide the search. A systematic literature review was performed to identify all the studies conducted on patients with ET published until September 2010. Articles were classified according to GRADE evidence profile, a system for grading the quality of evidence and the strength of recommendation based on the quality of the studies. The quality of evidence was often rated as "low" or "very low" for the studies analyzed. Propranolol, long-acting propranolol, primidone, and topiramate are recommended as first-line therapy, with restrictions for their side effects. Arotinolol, sotalol, ICI 118.551 and LI 32.468 (experimental drugs), zonisamide, gabapentin, alprazolam, clozapine, and olanzapine are recommended as a second-line treatment. Botulinum toxin type A and thalamic deep-brain stimulation are recommended for refractory ET. The results highlight the need of well-designed direct comparison trials aimed at evaluating relative effectiveness and safety of the drugs currently used in clinical practice. Furthermore, additional controlled clinical trials are required to define other possible treatment strategies for ameliorating the management of ET.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.