ReviewCurrent opinion in gastroenterology2012
Pathogenic mechanisms of acute pancreatitis.
Review in Current opinion in gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
79 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Protein sorting and proteostasis mechanisms in CFTR-related exocrine pancreas dysfunction: A systematic narrative review.Channels (Austin, Tex.) · 2026Pooled it
- Pooled it
- Integrating Bayesian Inference and Machine Learning to Evaluate TAP and Trypsin-2 as Early Biomarkers of Systemic Inflammation in Acute Pancreatitis.Medicina (Kaunas, Lithuania) · 2026Article
- Nano-Reagents in Acute Pancreatitis: Diagnostic, Therapeutic, and Theranostic Advances.International journal of nanomedicine · 2026Review
- Acute Pancreatitis Secondary to Hyperlipidemia After Exposure to Biktarvy and Alcohol in a HIV-Positive Patient:A Case Report.International medical case reports journal · 2026Article
- Methanol Extract fromAntioxidants (Basel, Switzerland) · 2025Article
- Multienzymatic nanocatalysts attenuate acute pancreatitis via dual modulation of pyroptotic pathways and autodigestion blockade.Journal of nanobiotechnology · 2025Article
- New advances of nanozymes for the diagnosis and treatment of digestive system diseases (Review).International journal of molecular medicine · 2025Review
- Assessing acute pancreatitis: A novel method combining live cell imaging with tissue damage evaluation.Histology and histopathology · 2025Article
- Biological and Molecular Characterization of FiveTropical medicine and infectious disease · 2025Article
- Artesunate protects against a mouse model of cerulein and lipopolysaccharide‑induced acute pancreatitis by inhibiting TLR4‑dependent autophagy.International journal of molecular medicine · 2025Article
- DGA ameliorates severe acute pancreatitis through modulating macrophage pyroptosis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024Article
- The TRIM28/miR133a/CD47 axis acts as a potential therapeutic target in pancreatic necrosis by impairing efferocytosis.Molecular therapy : the journal of the American Society of Gene Therapy · 2024Article
- Review
- Interleukins: pathophysiological role in acute pancreatitis.Archives of medical science : AMS · 2024Article
- Mmu_circ_0000037 inhibits the progression of acute pancreatitis by miR-92a-3p/Pias1 axis.Immunity, inflammation and disease · 2023Article
- Surgical management of acute pancreatitis: Historical perspectives, challenges, and current management approaches.World journal of gastrointestinal surgery · 2023Review
- Acute Pancreatitis Associated with Atypical Bacterial Pneumonia: Systematic Literature Review.Journal of clinical medicine · 2022Review
- Sphingosine 1-phosphate receptor 2 mediated early stages of pancreatic and systemic inflammatory responses via NF-kappa B activation in acute pancreatitis.Cell communication and signaling : CCS · 2022Article
- Identification of circulating extracellular vesicle long RNAs as diagnostic biomarkers for patients with severe acute pancreatitis.Clinical and translational medicine · 2022Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
purpose of reviewIn this article, recent advances in the pathogenesis of acute pancreatitis have been reviewed. RECENT
findingsPathologic intra-acinar trypsinogen activation had been hypothesized to be the central mechanism of pancreatitis for over a century. This hypothesis could be explored for the first time with the development of a novel mouse model lacking pathologic intra-acinar trypsinogen activation. It became clear that intra-acinar trypsinogen activation contributes to early acinar injury, but local and systemic inflammation progress independently during pancreatitis. Early intra-acinar nuclear factor kappa B (NFκB) activation, which occurs parallel to but independent of trypsinogen activation, may be crucial in pancreatitis. Although the mechanism of NFκB and trypsinogen activation is not entirely clear, further insights have been made into key pathogenic cellular events such as calcium signaling, mitochondrial dysfunction, endoplasmic reticulum (ER) stress, autophagy and impaired trafficking, and lysosomal and secretory responses. Cellular intrinsic damage-sensing mechanisms that lead to activation of the inflammatory response aimed at repair, but lead to disease when overwhelmed, are beginning to be understood. SUMMARY: New findings necessitate a paradigm shift in our understanding of acute pancreatitis. Intra-acinar trypsinogen activation leads to early pancreatic injury, but the inflammatory response of acute pancreatitis develops independently, driven by early activation of inflammatory pathways.
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