Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

1,199 citing papers in PubMed, 14 syntheses or guidelines pooled it, 2,003 citations in OpenAlex.

1. Challenges in interpreting Mendelian randomization studies with a disease as the exposure: Using COVID-19 liability studies as an exemplar.European journal of human genetics : EJHG · 2025
   Pooled it
2. Effects of GLP-1 Analogues and Agonists on the Gut Microbiota: A Systematic Review.Nutrients · 2025
   Pooled it
3. TCF7L2 as a target of peripheral artery disease in patients with type 2 diabetes: A 2-sample Mendelian randomization and bioinformatics study.Medicine · 2025
   Pooled it
4. Mendelian randomization study and meta-analysis exploring the causality of age at menarche and the risk of intracerebral hemorrhage and ischemic stroke.CNS neuroscience & therapeutics · 2023
   Pooled it
5. Models Predicting Postpartum Glucose Intolerance Among Women with a History of Gestational Diabetes Mellitus: a Systematic Review.Current diabetes reports · 2023
   Pooled it
6. Common and Distinct Genetic Architecture of Age at Diagnosis of Diabetes in South Indian and European Populations.Diabetes care · 2023
   Pooled it
7. Investigating causality in the association between DNA methylation and type 2 diabetes using bidirectional two-sample Mendelian randomisation.Diabetologia · 2023
   Pooled it
8. Pharmacogenetic interactions of medications administered for weight loss in adults: a systematic review and meta-analysis.Pharmacogenomics · 2023
   Pooled it
9. Genetic variation in cis-regulatory domains suggests cell type-specific regulatory mechanisms in immunity.Communications biology · 2023
   Pooled it
10. The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions.Nature genetics · 2023
    Pooled it
11. Assessment of the genetic and clinical determinants of hip fracture risk: Genome-wide association and Mendelian randomization study.Cell reports. Medicine · 2022
    Pooled it
12. Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes.Human molecular genetics · 2022
    Pooled it
13. Association of Genetic Predisposition and Physical Activity With Risk of Gestational Diabetes in Nulliparous Women.JAMA network open · 2022
    Pooled it
14. Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.Nature genetics · 2022
    Pooled it
15. Body mass index and type 2 diabetes liability in osteomyelitis and cellulitis: A cross-biobank Mendelian randomization study.Medicine · 2026
    Article
16. Single-cell analysis of chromatin accessibility in the human intestine identifies regulatory programs and clarifies genetic associations in Crohn's disease.Nature genetics · 2026
    Article
17. Three dimensional reconstruction of the human nucleus accumbens reveals topographic organization and molecular heterogeneity of D1-islands across the anterior posterior axis.bioRxiv : the preprint server for biology · 2026
    Article
18. CRISPR Technologies in Type 2 Diabetes: From Mechanistic Insights to Therapeutic Discovery.International journal of molecular sciences · 2026
    Review
19. Genetic architectures of brain-related traits are shaped by strong selective constraints.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
20. The Omnicausal Model Reveals the Highly Polyfactorial Nature of Complex Diseases.Genetic epidemiology · 2026
    Article

1,139 more citing papers are in PubMed but not listed here.

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

210 authors at 20 institutions in 18 countries.

Funding

Abstract

Indexed as