ArticlePsychopharmacology2013
Nicotine-induced enhancement of responding for conditioned reinforcement in rats: role of prior nicotine exposure and α4β2 nicotinic receptors.
Article in Psychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Clinical and preclinical evidence of sex differences in nicotine-induced enhancement of alcohol self-administration.Psychopharmacology · 2026Review
- Effects of nicotinic receptor antagonism on nicotine and THC self-administration in a model of polysubstance use.The international journal of neuropsychopharmacology · 2026Article
- Effects of nicotinic receptor antagonism on nicotine and THC self-administration in a model of polysubstance use.bioRxiv : the preprint server for biology · 2025Article
- Elucidating the reinforcing effects of nicotine: a tribute to Nadia Chaudhri.Psychopharmacology · 2023Review
- β2* nicotinic acetylcholine receptor subtypes mediate nicotine-induced enhancement of Pavlovian conditioned responding to an alcohol cue.Frontiers in behavioral neuroscience · 2022Article
- Nicotine-induced enhancement of a sensory reinforcer in adult rats: antagonist pretreatment effects.Psychopharmacology · 2021Article
- The pharmacological stressor yohimbine, but not U50,488, increases responding for conditioned reinforcers paired with ethanol or sucrose.Psychopharmacology · 2020Article
- Effects of 5-HTPsychopharmacology · 2017Article
- Nicotine-induced enhancement of Pavlovian alcohol-seeking behavior in rats.Psychopharmacology · 2017Article
- The tendency to sign-track predicts cue-induced reinstatement during nicotine self-administration, and is enhanced by nicotine but not ethanol.Psychopharmacology · 2016Article
- Individual Differences in the Attribution of Incentive Salience to a Pavlovian Alcohol Cue.Frontiers in behavioral neuroscience · 2016Article
- The attribution of incentive salience to Pavlovian alcohol cues: a shift from goal-tracking to sign-tracking.Frontiers in behavioral neuroscience · 2015Article
- Responding for conditioned reinforcement in C57BL/6 and CD-1 mice, and Sprague-Dawley rats: Effects of methylphenidate and amphetamine.Psychopharmacology · 2014Article
- The effects of nicotine exposure during Pavlovian conditioning in rats on several measures of incentive motivation for a conditioned stimulus paired with water.Psychopharmacology · 2014Article
- Synergistic interaction between caloric restriction and amphetamine in food-unrelated approach behavior of rats.Psychopharmacology · 2014Article
- The form of a conditioned stimulus can influence the degree to which it acquires incentive motivational properties.PloS one · 2014Article
- Reinforcement enhancing effects of nicotine via smoking.Psychopharmacology · 2013Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleStimuli associated with nicotine can become motivationally significant and may play a role in tobacco dependence. Previous work indicates that nicotine enhances responding for a conditioned reinforcer (CR).
objectivesThese studies examined the effects of prior exposure to nicotine on responding for a CR, persistence of this response, and the role of α4β2 or α7 nicotinic receptor subtypes.
methodsWater deprived rats were given 13 Pavlovian conditioning sessions where a light/tone conditioned stimulus (CS) was paired with the delivery of water. Then, rats were presented with two levers: one delivered the CS (now a CR), the other was inactive. Experiments examined the effect of nicotine administered prior to Pavlovian conditioning sessions on approach behavior during CS presentations, operant responding for CR in the presence and absence of nicotine, and the persistence of responding for CR. The effects of nicotinic acetylcholine receptor (nAChR) antagonism with mecamylamine and α4β2 or α7 nAChR antagonism with dihydro-beta-erythroidine (DHβE) or methyllycaconitine (MLA) on nicotine-enhanced responding for CR were examined.
resultsNicotine enhanced approach behavior during CS presentations and potentiated operant responding for CR, an effect sensitized as a result of nicotine exposure during conditioning. Responding for CR and its potentiation by nicotine was stable over multiple tests. Enhanced responding for the CR induced by nicotine was blocked by mecamylamine and DHβE, but not MLA.
conclusionsNicotine enhances Pavlovian discriminated approach and shows sensitized nicotine-induced enhancements in responding for CR, an effect depending on α4β2 nAChRs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.