ArticleThe Plant cell2012
Stress-induced GSK3 regulates the redox stress response by phosphorylating glucose-6-phosphate dehydrogenase in Arabidopsis.
Article in The Plant cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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Who cites it
83 citing papers in PubMed.
- Antisense Oligonucleotides as a Gene-Silencing Strategy Regulating Cytosolic G6PDH inPlants (Basel, Switzerland) · 2026Article
- Genome-Wide Identification, Characterization, Expression Analysis, and Interacting Protein Prediction of thePlants (Basel, Switzerland) · 2026Article
- Glucose-6-Phosphate Dehydrogenase ModulatesMolecules (Basel, Switzerland) · 2025Article
- Evidence for peroxisomal redundancy among the glucose-6-phosphate dehydrogenase isoforms of Arabidopsis thaliana.Plant & cell physiology · 2025Article
- Lipid metabolism improves salt tolerance of Salicornia europaea.Annals of botany · 2025Article
- CDK5-triggered G6PD phosphorylation at threonine 91 facilitating redox homeostasis reveals a vulnerability in breast cancer.Acta pharmaceutica Sinica. B · 2025Article
- Identification of GSK3 Family Genes in Pear and Their Expression Analysis Under Drought Stress.Life (Basel, Switzerland) · 2025Article
- The maize GSK3-like kinase ZmSK1 negatively regulates drought tolerance by phosphorylating the transcription factor ZmCPP2.The Plant cell · 2025Article
- PpSKα boosts chilling tolerance by activating PpTrxh9 in peach fruit.Frontiers in plant science · 2025Article
- Phosphorylation of birch BpNAC90 improves the activation of gene expression to confer drought tolerance.Horticulture research · 2024Article
- The chromosome-scale genome and population genomics reveal the adaptative evolution ofHorticulture research · 2024Article
- Article
- In Vivo Phosphorylation of the Cytosolic Glucose-6-Phosphate Dehydrogenase Isozyme G6PD6 in Phosphate-ResuppliedPlants (Basel, Switzerland) · 2023Article
- HbBIN2 Functions in Plant Cold Stress Resistance through Modulation of HbICE1 Transcriptional Activity and ROS Homeostasis inInternational journal of molecular sciences · 2023Article
- Reactive Oxygen Species in Drought-Induced Stomatal Closure: The Potential Roles of NPR1.Plants (Basel, Switzerland) · 2023Article
- Regulatory network of GSK3-like kinases and their role in plant stress response.Frontiers in plant science · 2023Review
- A Chloroplast-Localized Glucose-6-Phosphate Dehydrogenase Positively Regulates Stripe Rust Resistance in Wheat.International journal of molecular sciences · 2022Article
- Glucose-6-Phosphate Dehydrogenases: The Hidden Players of Plant Physiology.International journal of molecular sciences · 2022Review
- Role of Plasma Membrane NADPH Oxidase in Response to Salt Stress in Cucumber Seedlings.Antioxidants (Basel, Switzerland) · 2022Article
- Genome-Wide Investigation of G6PDH Gene in Strawberry: Evolution and Expression Analysis during Development and Stress.International journal of molecular sciences · 2022Article
23 more citing papers are in PubMed but not listed here.
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10 authors.
Funding
Abstract
Diverse stresses such as high salt conditions cause an increase in reactive oxygen species (ROS), necessitating a redox stress response. However, little is known about the signaling pathways that regulate the antioxidant system to counteract oxidative stress. Here, we show that a Glycogen Synthase Kinase3 from Arabidopsis thaliana (ASKα) regulates stress tolerance by activating Glc-6-phosphate dehydrogenase (G6PD), which is essential for maintaining the cellular redox balance. Loss of stress-activated ASKα leads to reduced G6PD activity, elevated levels of ROS, and enhanced sensitivity to salt stress. Conversely, plants overexpressing ASKα have increased G6PD activity and low levels of ROS in response to stress and are more tolerant to salt stress. ASKα stimulates the activity of a specific cytosolic G6PD isoform by phosphorylating the evolutionarily conserved Thr-467, which is implicated in cosubstrate binding. Our results reveal a novel mechanism of G6PD adaptive regulation that is critical for the cellular stress response.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.