ArticleJournal of lower genital tract disease2013
The correlation between human papillomavirus positivity and abnormal cervical cytology result differs by age among perimenopausal women.
Article in Journal of lower genital tract disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Worldwide burden of cervical human papillomavirus (HPV) in women over 50 years with abnormal cytology: a systematic review and meta-analysis.BMJ global health · 2025Pooled it
- Integrating a "see-and-treat" approach with opportunistic human papilloma virus deoxyribonucleic acid (HPV DNA) based cervical cancer screening in India: a retrospective cross-sectional study.AJOG global reports · 2026Article
- Expanded HPV Genotyping by Single-Tube Nested-Multiplex PCR May Explain HPV-Related Disease Recurrence.Microorganisms · 2024Article
- Awareness of Human Papillomavirus among Male and Female University Students in Saudi Arabia.Healthcare (Basel, Switzerland) · 2023Article
- Incidence of oncogenic HPV and HPV-related dysplasia five years after a negative HPV test by self-sampling in elderly women.Infectious agents and cancer · 2022Article
- Article
- Genetic instability and anti-HPV immune response as drivers of infertility associated with HPV infection.Infectious agents and cancer · 2021Review
- Evaluation of PCR-Reverse Dot Blot Human Papillomavirus Genotyping Test in Predicting Residual/Recurrent CIN 2+ in Posttreatment Patients in China.Cancer management and research · 2020Article
- Participation in Cervical Screening by Self-collection, Pap, or a Choice of Either in Brazil.Cancer prevention research (Philadelphia, Pa.) · 2019Article
- Similar Risk Patterns After Cervical Screening in Two Large U.S. Populations: Implications for Clinical Guidelines.Obstetrics and gynecology · 2016Article
- Article
- Evidence of disrupted high-risk human papillomavirus DNA in morphologically normal cervices of older women.Scientific reports · 2016Article
- Risk Stratification Using Human Papillomavirus Testing among Women with Equivocally Abnormal Cytology: Results from a State-Wide Surveillance Program.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2016Article
- Age-stratified 5-year risks of cervical precancer among women with enrollment and newly detected HPV infection.International journal of cancer · 2015Article
- Association between the vaginal microbiota, menopause status, and signs of vulvovaginal atrophy.Menopause (New York, N.Y.) · 2014Article
- A cohort effect of the sexual revolution may be masking an increase in human papillomavirus detection at menopause in the United States.The Journal of infectious diseases · 2013Article
- Contributions of recent and past sexual partnerships on incident human papillomavirus detection: acquisition and reactivation in older women.Cancer research · 2012Article
- Evidence and impact of human papillomavirus latency.The open virology journal · 2012Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
Abstract
objectivesWe explored the age-stratified correlates and correlations between high-risk human papillomavirus (HR-HPV) infection and cervical abnormalities in perimenopausal women. MATERIALS AND
methodsHuman papillomavirus testing and Pap smear screening were performed at baseline on 841 routinely screened women age 35 to 60 years in the HPV in perimenopause cohort. Demographic, behavioral, and medical information was collected through telephone-administered questionnaires. Descriptive analyses were used to examine the correlation between HR-HPV infection and cervical abnormalities by age. Logistic regression was used to determine correlates of HPV and abnormalities in women younger and older than 45 years.
resultsThe prevalence of HPV, HR-HPV, and cervical abnormalities decreased significantly with increasing age, as did the correlation between HR-HPV and cervical abnormalities. The prevalence of HR-HPV was 50% among younger women with abnormalities but this decreased steadily to 20% HR-HPV detection among 50- to 54-year-old women, and no abnormalities were detected in 55- to 60-year-old women. Different correlates of HR-HPV infection and abnormalities were observed in women 45 years or older, a pattern not seen in younger women.
conclusionsAlthough the relative proportion of low-grade and high-grade abnormalities did not change with age, we saw a loss of concordance between HR-HPV detection and cytological abnormalities with increasing age. Current guidelines for cervical cancer screening group together all women age 30 years and older. Our data raise important questions about the interpretation of HPV and Pap test results in this age group and suggest that ongoing surveillance of HPV and cytology in cervical cancer screening programs consider a third age stratification among older women.
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