Trial reportPrimary care respiratory journal : journal of the General Practice Airways Group2012
Association of dietary soy genistein intake with lung function and asthma control: a post-hoc analysis of patients enrolled in a prospective multicentre clinical trial.
Trial report in Primary care respiratory journal : journal of the General Practice Airways Group, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Vitamins C and E for asthma and exercise-induced bronchoconstriction.The Cochrane database of systematic reviews · 2014Pooled it
- Vitamin C for asthma and exercise-induced bronchoconstriction.The Cochrane database of systematic reviews · 2013Pooled it
- Soy isoflavones reduce asthma exacerbation in asthmatic patients with high PAI-1-producing genotypes.The Journal of allergy and clinical immunology · 2019Trial
- Trial
- Isoflavone Intake is Associated With Decreased Chronic Obstructive Pulmonary Disease Morbidity.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2026Article
- Association of the gut microbiome and metabolome with wheeze frequency in childhood asthma.The Journal of allergy and clinical immunology · 2022Article
- Review
- The Fermented Soy Product ImmuBalanceNutrients · 2021Article
- The upshot of Polyphenolic compounds on immunity amid COVID-19 pandemic and other emerging communicable diseases: An appraisal.Natural products and bioprospecting · 2020Review
- Dietary flavonoids and respiratory diseases: a population-based multi-case-control study in Italian adults.Public health nutrition · 2020Article
- Dietary Intake of Flavonoids and Ventilatory Function in European Adults: A GA²LEN Study.Nutrients · 2018Article
- Effects of resveratrol and genistein on nuclear factor‑κB, tumor necrosis factor‑α and matrix metalloproteinase‑9 in patients with chronic obstructive pulmonary disease.Molecular medicine reports · 2016Article
- Can dietary interventions improve asthma control?Primary care respiratory journal : journal of the General Practice Airways Group · 2012Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundBroad dietary patterns have been linked to asthma but the relative contribution of specific nutrients is unclear. Soy genistein has important anti-inflammatory and other biological effects that might be beneficial in asthma. A positive association was previously reported between soy genistein intake and lung function but not with asthma exacerbations.
aimsTo conduct a post-hoc analysis of patients with inadequately controlled asthma enrolled in a prospective multicentre clinical trial to replicate this association.
methodsA total of 300 study participants were included in the analysis. Dietary soy genistein intake was measured using the Block Soy Foods Screener. The level of soy genistein intake (little or no intake, moderate intake, or high intake) was compared with baseline lung function (pre-bronchodilator forced expiratory volume in 1 second (FEV(1))) and asthma control (proportion of participants with an episode of poor asthma control (EPAC) and annualised rates of EPACs over a 6-month follow-up period.
resultsParticipants with little or no genistein intake had a lower baseline FEV(1) than those with a moderate or high intake (2.26 L vs. 2.53 L and 2.47 L, respectively; p=0.01). EPACs were more common among those with no genistein intake than in those with a moderate or high intake (54% vs. 35% vs. 40%, respectively; p<0.001). These findings remained significant after adjustment for patient demographics and body mass index.
conclusionsIn patients with asthma, consumption of a diet with moderate to high amounts of soy genistein is associated with better lung function and better asthma control.
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