ArticleEpigenetics2012
Semen samples showing an increased rate of spermatozoa with imprinting errors have a negligible effect in the outcome of assisted reproduction techniques.
Article in Epigenetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- H19 Sperm Methylation in Male Infertility: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2023Pooled it
- Septins as key players in spermatogenesis, fertilisation and pre-implantation embryogenic cytoplasmic dynamics.Cell communication and signaling : CCS · 2024Review
- Does SpermBiomedicines · 2024Review
- Epigenetics of Male Infertility: The Role of DNA Methylation.Frontiers in cell and developmental biology · 2021Review
- The sperm epigenome does not display recurrent epimutations in patients with severely impaired spermatogenesis.Clinical epigenetics · 2020Article
- Association of UHRF1 gene polymorphisms with oligospermia in Chinese males.Journal of assisted reproduction and genetics · 2019Article
- Epigenetics of Male Fertility: Effects on Assisted Reproductive Techniques.The world journal of men's health · 2019Review
- Genetic and epigenetic profiling of the infertile male.PloS one · 2019Article
- Sperm chromatin and DNA integrity, methyltransferase mRNA levels, and global DNA methylation in oligoasthenoteratozoospermia.Clinical and experimental reproductive medicine · 2018Article
- Imprinting alterations in sperm may not significantly influence ART outcomes and imprinting patterns in the cord blood of offspring.PloS one · 2017Article
- The role of epigenetics in idiopathic male infertility.Journal of assisted reproduction and genetics · 2016Review
- High-dose folic acid supplementation alters the human sperm methylome and is influenced by the MTHFR C677T polymorphism.Human molecular genetics · 2015Article
- Absence of sperm RNA elements correlates with idiopathic male infertility.Science translational medicine · 2015Article
- Article
- OMICS: Current and future perspectives in reproductive medicine and technology.Journal of human reproductive sciences · 2014Review
- Epigenetic regulation of the RHOX homeobox gene cluster and its association with human male infertility.Human molecular genetics · 2014Article
- Lack of association of MTHFR rs1801133 polymorphism and CTCFL mutations with sperm methylation errors in infertile patients.Journal of assisted reproduction and genetics · 2013Article
- Bringing epigenetics into the diagnostics of the andrology laboratory: challenges and perspectives.Asian journal of andrologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The topic of imprinting defects present in the sperm of infertile patients has been addressed by several reports in the last few years. However, whether methylation abnormalities at one or few CpGs within an imprinted locus are pathological is a matter of debate. Moreover, whether imprinting anomalies in sperm could interfere with fertility treatment outcomes is still unknown. In this report we analyze the sperm DNA methylation profile of H19-ICR, KvDMR, SNRPN-ICR, IG-DMR and MEG3-DMR by pyrosequencing in 107 infertile men series and a control population of 30 proven fertile males. DNA methylation was statistically evaluated from two points of view: first, the methylation of each CpG was analyzed in the control population and the mean, standard deviation and range were determined and compared with infertile population data; second, in order to define altered methylation patterns for each region, a hierarchical cluster analysis was performed by which individuals were grouped in different clusters according to the degree of similarity of their methylation pattern. Two pieces of data supported the results obtained in the multi-variate analysis: the classification of the vast majority of control individuals in clusters with normal methylation patterns and the significant differences in methylation levels found between individuals within the normal and abnormal clusters. Individuals included in normal and abnormal methylation clusters were compared according to seminal parameters as well as to the outcome of assisted reproduction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.