ArticleNucleic acids research2012
A novel Plasmodium falciparum SR protein is an alternative splicing factor required for the parasites' proliferation in human erythrocytes.
Article in Nucleic acids research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Identification of serine/arginine-rich splicing factor 1-interacting proteins in Plasmodium berghei.Malaria journal · 2026Article
- A tale of two parasites: a glimpse into the RNA methylome of patient-derived Plasmodium falciparum and Plasmodium vivax isolates.Malaria journal · 2025Article
- Single-cell transcriptomics reveal transcriptional programs underlying male and female cell fate during Plasmodium falciparum gametocytogenesis.Nature communications · 2024Article
- The splicing factor SR2 is an important virulence factor ofFrontiers in microbiology · 2023Article
- Emerging biology of noncoding RNAs in malaria parasites.PLoS pathogens · 2022Review
- A Leak-Free Inducible CRISPRi/a System for Gene Functional Studies in Plasmodium falciparum.Microbiology spectrum · 2022Article
- Transcriptomic complexity of the human malaria parasite Plasmodium falciparum revealed by long-read sequencing.PloS one · 2022Article
- An SR protein is essential for activating DNA repair in malaria parasites.Journal of cell science · 2021Article
- Phosphorylation of the Canonical Histone H2A Marks Foci of Damaged DNA in Malaria Parasites.mSphere · 2021Article
- Roles and Cellular Localization of GBP2 and NAB2 During the Blood Stage of Malaria Parasites.Frontiers in cellular and infection microbiology · 2021Article
- An Update on Development of Small-Molecule Plasmodial Kinase Inhibitors.Molecules (Basel, Switzerland) · 2020Review
- Specific inhibition of splicing factor activity by decoy RNA oligonucleotides.Nature communications · 2019Article
- Review
- An upstream open reading frame (uORF) signals for cellular localization of the virulence factor implicated in pregnancy associated malaria.Nucleic acids research · 2018Article
- Translational regulation in blood stages of the malaria parasite Plasmodium spp.: systems-wide studies pave the way.Wiley interdisciplinary reviews. RNA · 2016Review
- Single-target high-throughput transcription analyses reveal high levels of alternative splicing present in the FPPS/GGPPS from Plasmodium falciparum.Scientific reports · 2015Article
- A bioinformatic survey of RNA-binding proteins in Plasmodium.BMC genomics · 2015Article
- A serine-arginine-rich (SR) splicing factor modulates alternative splicing of over a thousand genes in Toxoplasma gondii.Nucleic acids research · 2015Article
- Transcript maturation in apicomplexan parasites.Current opinion in microbiology · 2014Review
- The role played by alternative splicing in antigenic variability in human endo-parasites.Parasites & vectors · 2014Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Malaria parasites have a complex life cycle, during which they undergo significant biological changes to adapt to different hosts and changing environments. Plasmodium falciparum, the species responsible for the deadliest form of human malaria, maintains this complex life cycle with a relatively small number of genes. Alternative splicing (AS) is an important post-transcriptional mechanisms that enables eukaryotic organisms to expand their protein repertoire out of relatively small number of genes. SR proteins are major regulators of AS in higher eukaryotes. Nevertheless, the regulation of splicing as well as the AS machinery in Plasmodium spp. are still elusive. Here, we show that PfSR1, a putative P. falciparum SR protein, can mediate RNA splicing in vitro. In addition, we show that PfSR1 functions as an AS factor in mini-gene in vivo systems similar to the mammalian SR protein SRSF1. Expression of PfSR1-myc in P. falciparum shows distinct patterns of cellular localization during intra erythrocytic development. Furthermore, we determine that the predicted RS domain of PfSR1 is essential for its localization to the nucleus. Finally, we demonstrate that proper regulation of pfsr1 is required for parasite proliferation in human RBCs and over-expression of pfsr1 influences AS activity of P. falciparum genes in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.