ArticleThe Indian journal of medical research2012
Risk factors associated with the development of overt nephropathy in type 2 diabetes patients: a 12 years observational study.
Article in The Indian journal of medical research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 57 citations in OpenAlex.
- Implementation of Established Global Guidelines in the Management of CKD in Patients with Type 2 Diabetes in Asia.Clinical journal of the American Society of Nephrology : CJASN · 2025Article
- L-shaped association between fasting blood glucose and urea in a non-diabetic population.Frontiers in nutrition · 2025Article
- Prevalence of chronic kidney disease in Tunisian diabetics: the TUN-CKDD survey.BMC nephrology · 2024Observational
- Diabetes, Hypertension, and Incidence of Chronic Kidney Disease: Is There any Multiplicative or Additive Interaction?International journal of endocrinology and metabolism · 2021Article
- The burden of unrecognised chronic kidney disease in patients with type 2 diabetes at a county hospital clinic in Kenya: implications to care and need for screening.BMC nephrology · 2020Article
- Impaired Glomerular Filtration Rate in Type 2 Diabetes Mellitus Subjects: A Nationwide Cross-Sectional Study in Thailand.Journal of diabetes research · 2020Article
- Hyperglycemia potentiates the effect of ionic calcium in photoreceptor ellipsoid zone disruption in diabetic retinopathy.International ophthalmology · 2019Observational
- Blood pressure control in diabetes-the Indian perspective.Journal of human hypertension · 2019Review
- Critical role of endoplasmic reticulum stress in chronic endothelial activation-induced visual deficits in tie2-tumor necrosis factor mice.Journal of cellular biochemistry · 2018Article
- The Global Epidemiology of Diabetes and Kidney Disease.Advances in chronic kidney disease · 2018Review
- Poor glycaemic control and its metabolic and demographic risk factors in a Malaysian community-based study.International journal of public health · 2018Article
- A non-laboratory-based risk score for predicting diabetic kidney disease in Chinese patients with type 2 diabetes.Oncotarget · 2017Article
- Prevalence of type 2 diabetes and its complications in India and economic costs to the nation.European journal of clinical nutrition · 2017Review
- Glomerular Hyperfiltration in Diabetes: Mechanisms, Clinical Significance, and Treatment.Journal of the American Society of Nephrology : JASN · 2017Review
- Pro- and antiangiogenic VEGF and its receptor status for the severity of diabetic retinopathy.Molecular vision · 2017Article
- Comparing of Cox model and parametric models in analysis of effective factors on event time of neuropathy in patients with type 2 diabetes.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2017Article
- Determinants of diabetic nephropathy in Ayder Referral Hospital, Northern Ethiopia: A case-control study.PloS one · 2017Article
- Age as an independent factor for the development of neuropathy in diabetic patients.Clinical interventions in aging · 2016Article
- Role of alteration in Treg/Th17 cells' balance in nephropathic patients with Type 2 diabetes mellitus.Electronic physician · 2015Article
- Diabetic nephropathy and its risk factors in a society with a type 2 diabetes epidemic: a Saudi National Diabetes Registry-based study.PloS one · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND &
objectivesDiabetic nephropathy (DN) is the leading cause of chronic kidney disease and end-stage renal disease in developing countries. Early detection and risk reduction measures can prevent DN. The aim of the study was to determine the risk factors for the development of proteinuria over a period of 12 years of follow up in normoalbuminuric type 2 diabetes patients attending a specialized centre.
methodsOf the 2630 type 2 diabetes subjects newly registered in 1996, 152 (M:F;92:60) normoalbuminuric subjects had baseline and subsequent measurements of anthropometric, haemodynamic and biochemical details spanning 12 years. The subjects were divided into 2 groups based on the renal status during follow up visits. Group 1 (non-progressors) had persistent normoalbuminuria and group 2 (progressors) had persistent proteinuria. Presence of other diabetic complications during follow up and details on antidiabetic and antihypertensive agents were noted.
resultsDuring median follow up of 11 years in subjects with normal renal function at baseline, 44.1 per cent developed proteinuria at follow up. Glucose levels, HbA 1 c, systolic blood pressure (SBP), triglycerides, and urea levels were significantly higher at baseline among progressors than non-progressors. Progressors had a longer duration of diabetes and significant fall in estimated glomerular filtration rate (eGFR) levels at follow up. In Cox's regression analysis, baseline age, duration of diabetes, baseline HbA 1 c and mean values of HbA 1 c, triglycerides, SBP and presence of retinopathy showed significant association with the development of macroalbuminuria. INTERPRETATION &
conclusionsType 2 diabetes patients with uncontrolled diabetes and increase in blood pressure are at high risk of developing nephropathy. Age, long duration of diabetes, elevated BP, poor glycaemic control and presence of retinopathy were significantly associated with the progression of diabetic nephropathy.
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22885263PMC3461717W2126831204What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.