ArticleCurrent biology : CB2012
Reconsolidation of long-term memory in Aplysia.
Article in Current biology : CB, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Improvements in operant memory ofFrontiers in behavioral neuroscience · 2023Article
- Evolution of memory system-related genes.FEBS open bio · 2021Review
- Larval zebrafish display dynamic learning of aversive stimuli in a constant visual surrounding.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Memory Destabilization and Reconsolidation Dynamically Regulate the PKMζ Maintenance Mechanism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Features of behavioral changes underlying conditioned taste aversion in the pond snail Lymnaea stagnalis.Invertebrate neuroscience : IN · 2020Article
- Effects of Thryptophan Hydroxylase Blockade by P-Chlorophenylalanine on Contextual Memory Reconsolidation after Training of Different Intensity.International journal of molecular sciences · 2020Article
- Monoamines, Insulin and the Roles They Play in Associative Learning in Pond Snails.Frontiers in behavioral neuroscience · 2019Review
- Impairing of Serotonin Synthesis by P-Chlorphenylanine Prevents the Forgetting of Contextual Memory After Reminder and the Protein Synthesis Inhibition.Frontiers in pharmacology · 2018Article
- Memory Synapses Are Defined by Distinct Molecular Complexes: A Proposal.Frontiers in synaptic neuroscience · 2018Review
- Prior Learning of Relevant Nonaversive Information Is a Boundary Condition for Avoidance Memory Reconsolidation in the Rat Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Role of protein synthesis and DNA methylation in the consolidation and maintenance of long-term memory ineLife · 2017Article
- Impairment of the serotonergic neurons underlying reinforcement elicits extinction of the repeatedly reactivated context memory.Scientific reports · 2016Article
- Transcription inhibitors prevent amnesia induced by NMDA antagonist-mediated impairment of memory reconsolidation.Learning & behavior · 2016Article
- Frequency-specific stimulations induce reconsolidation of long-term potentiation in freely moving rats.Molecular brain · 2016Article
- Persistent Associative Plasticity at an Identified Synapse Underlying Classical Conditioning Becomes Labile with Short-Term Homosynaptic Activation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Reconsolidation and the Dynamic Nature of Memory.Cold Spring Harbor perspectives in biology · 2015Review
- Reinstatement of long-term memory following erasure of its behavioral and synaptic expression in Aplysia.eLife · 2014Article
- Persistent long-term facilitation at an identified synapse becomes labile with activation of short-term heterosynaptic plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Unraveling the complexities of circadian and sleep interactions with memory formation through invertebrate research.Frontiers in systems neuroscience · 2014Review
- Memory reconsolidation in aversive and appetitive settings.Frontiers in behavioral neuroscience · 2013Review
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
When an animal is reminded of a prior experience and shortly afterward treated with a protein synthesis inhibitor, the consolidated memory for the experience can be disrupted; by contrast, protein synthesis inhibition without prior reminding commonly does not disrupt long-term memory [1-3]. Such results imply that the reminding triggers reconsolidation of the memory. Here, we asked whether the behavioral and synaptic changes associated with the memory for long-term sensitization (LTS) of the siphon-withdrawal reflex in the marine snail Aplysia californica [4, 5] could undergo reconsolidation. In support of this idea, we found that when sensitized animals were given abbreviated reminder sensitization training 48-96 hr after the original sensitization training, followed by treatment with the protein synthesis inhibitor anisomycin, LTS was disrupted. We also found that long-term (≥ 24 hr) facilitation (LTF) [6], which can be induced in the monosynaptic connection between Aplysia sensory and motor neurons in dissociated cell culture by multiple spaced pulses of the endogenous facilitatory transmitter serotonin (5-HT) [7, 8], could be eliminated by treating the synapses with one reminder pulse of 5-HT, followed by anisomycin, at 48 hr after the original training. Our results provide a simple model system for understanding the synaptic basis of reconsolidation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.