ArticleCell reports2012
Target-derived matricryptins organize cerebellar synapse formation through α3β1 integrins.
Article in Cell reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 48 citations in OpenAlex.
- An update on the landscape of collagen bioactive fragments.The FEBS journal · 2026Review
- The nonfibrillar multiplexin collagen CLE-1 defines cholinergic synapse identity.Science advances · 2025Article
- COMP Is a Biomarker of Cartilage Destruction, Extracellular Matrix and Vascular Remodeling and Tissue Repair.International journal of molecular sciences · 2025Review
- The extracellular matrix molecule Collagen XVIII/CLE-1 affects neuronal dendritic spines.microPublication biology · 2024Article
- Extracellular matrix and synapse formation.Bioscience reports · 2023Article
- Collagen XIX is required for pheromone recognition and glutamatergic synapse formation in mouse accessory olfactory bulb.Frontiers in cellular neuroscience · 2023Article
- Proteolysis: a key post-translational modification regulating proteoglycans.American journal of physiology. Cell physiology · 2022Review
- Development of astrocyte morphology and function in mouse visual thalamus.The Journal of comparative neurology · 2022Article
- Paracrine Role for Somatostatin Interneurons in the Assembly of Perisomatic Inhibitory Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Role of Endogenous Regulators of Hem- And Lymphangiogenesis in Corneal Transplantation.Journal of clinical medicine · 2020Review
- Coding Capacity of Purkinje Cells With Different Schemes of Morphological Reduction.Frontiers in computational neuroscience · 2019Article
- From Structure to Phenotype: Impact of Collagen Alterations on Human Health.International journal of molecular sciences · 2018Review
- Collagen 18 and agrin are secreted by neural crest cells to remodel their microenvironment and regulate their migration during enteric nervous system development.Development (Cambridge, England) · 2018Article
- F-spondin Is Essential for Maintaining Circadian Rhythms.Frontiers in neural circuits · 2018Article
- Optic Nerve Hypoplasia Is a Pervasive Subcortical Pathology of Visual System in Neonates.Investigative ophthalmology & visual science · 2017Article
- Activity-dependent proteolytic cleavage of cell adhesion molecules regulates excitatory synaptic development and function.Neuroscience research · 2017Review
- Loss of Interneuron-Derived Collagen XIX Leads to a Reduction in Perineuronal Nets in the Mammalian Telencephalon.ASN neuro · 2017Article
- Region- and Cell-Specific Expression of Transmembrane Collagens in Mouse Brain.Frontiers in integrative neuroscience · 2017Article
- Collagen-derived matricryptins promote inhibitory nerve terminal formation in the developing neocortex.The Journal of cell biology · 2016Article
- The anti-tumor NC1 domain of collagen XIX inhibits the FAK/ PI3K/Akt/mTOR signaling pathway through αvβ3 integrin interaction.Oncotarget · 2016Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
Trans-synaptic organizing cues must be passed between synaptic partners for synapses to properly form. Much of our understanding of this process stems from studies at the neuromuscular junction, where target-derived growth factors, extracellular matrix (ECM) molecules, and matricryptins (proteolytically released fragments of ECM molecules) are all essential for the formation and maintenance of motor nerve terminals. While growth factors and ECM molecules also contribute to the formation of brain synapses, it remains unclear whether synaptic roles exist for matricryptins in the mammalian brain. We report that collagen XVIII and its matricryptin endostatin are generated by cerebellar Purkinje cells and are necessary for the organization of climbing fiber terminals in these neurons. Moreover, endostatin is sufficient to induce climbing fiber terminal formation in vitro by binding and signaling through α3β1 integrins. Taken together, these studies reveal roles for both matricryptins and integrins in the organization of brain synapses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.