Trial reportNeuron2012
Dopamine enhances model-based over model-free choice behavior.
Trial report in Neuron, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
142 citing papers in PubMed, 322 citations in OpenAlex.
- Dopamine and Temporal Discounting: Revisiting Pharmacology and Individual Differences.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Trial
- The catecholamine precursor Tyrosine reduces autonomic arousal and decreases decision thresholds in reinforcement learning and temporal discounting.PLoS computational biology · 2022Trial
- Cortical dopamine reduces the impact of motivational biases governing automated behaviour.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Trial
- Reward and avoidance learning in the context of aversive environments and possible implications for depressive symptoms.Psychopharmacology · 2019Trial
- Levodopa does not affect expression of reinforcement learning in older adults.Scientific reports · 2019Trial
- Dopamine Increases a Value-Independent Gambling Propensity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Trial
- Valence-dependent influence of serotonin depletion on model-based choice strategy.Molecular psychiatry · 2016Trial
- Dopamine modulates the neural representation of subjective value of food in hungry subjects.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Trial
- Differential, but not opponent, effects of L -DOPA and citalopram on action learning with reward and punishment.Psychopharmacology · 2014Trial
- Dopamine restores reward prediction errors in old age.Nature neuroscience · 2013Trial
- Trial
- Model-based and model-free valuation signals in the human brain vary markedly in relation to individual differences in behavioral control.Cell reports · 2026Article
- The prefrontal-striatal signatures of reduced model-based learning in depressed patients.Annals of general psychiatry · 2026Article
- Thalamic regulation of reinforcement learning strategies across prefrontal-striatal networks.Nature communications · 2025Article
- Physical Activity Is Positively Associated with Model-Based Decision-Making in Pursuit of Reward in Trauma-Exposed Adults.Medicine and science in sports and exercise · 2025Article
- Higher motivation and pleasure scores predict more reliance on model-free decision making.Cognitive, affective & behavioral neuroscience · 2025Article
- Model-based and model-free valuation signals in the human brain vary markedly in their relationship to individual differences in behavioral control.bioRxiv : the preprint server for biology · 2025Article
- Cognitive computational model reveals repetition bias in a sequential decision-making task.Communications psychology · 2025Article
- Distributional dual-process model predicts strategic shifts in decision-making under uncertainty.Communications psychology · 2025Article
- Exploring Habits in Anorexia Nervosa: Promise, Pitfalls, and Progress.Current psychiatry reports · 2025Review
82 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Decision making is often considered to arise out of contributions from a model-free habitual system and a model-based goal-directed system. Here, we investigated the effect of a dopamine manipulation on the degree to which either system contributes to instrumental behavior in a two-stage Markov decision task, which has been shown to discriminate model-free from model-based control. We found increased dopamine levels promote model-based over model-free choice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.