ArticleCell reports2012
Transcriptome analysis of the planarian eye identifies ovo as a specific regulator of eye regeneration.
Article in Cell reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers.
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Who cites it
124 citing papers in PubMed, 215 citations in OpenAlex.
- Combinatorial mechanisms specify cellular location and neurotransmitter identity during planarian neurogenesis.Nature communications · 2026Article
- Niche-dependent modular regulation of the stem cell transcriptome separates cell identity and potential.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Single-cell transcriptomics and RNAi screening define a hierarchical program of planarian eye regeneration.Cell reports · 2026Article
- The Sensory Basis of Planarian Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Article
- Extracellular vesicles mediate stem cell signaling and systemic RNAi in planarians.Science advances · 2026Article
- Evolutionary dynamics of FoxQ2 transcription factors across metazoans reveals three ancient paralogs.Communications biology · 2025Article
- A genetically tractable non-vertebrate system to study complete camera-type eye regeneration.Nature communications · 2025Article
- Review
- Developmental onset of planarian whole-body regeneration depends on axis reset.Current biology : CB · 2025Article
- map3k1 suppresses terminal differentiation of migratory eye progenitors in planarian regeneration.PLoS genetics · 2025Article
- Stem cells (neoblasts) and positional information jointly dominate regeneration in planarians.Heliyon · 2025Review
- Reduced adult stem cell fate specification led to eye reduction in cave planarians.Nature communications · 2025Article
- Coordinated neuron-glia regeneration through Notch signaling in planarians.PLoS genetics · 2025Article
- Article
- Adaptive robustness through incoherent signaling mechanisms in a regenerative brain.Cell reports · 2024Article
- Development of the Binocular Circuit.Annual review of neuroscience · 2024Review
- Neoblast-like stem cells of Fasciola hepatica.PLoS pathogens · 2024Article
- A transcription factor atlas of stem cell fate in planarians.Cell reports · 2024Article
- LIM-HD transcription factors control axial patterning and specify distinct neuronal and intestinal cell identities in planarians.Open biology · 2023Article
64 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Among the millions of invertebrate species with visual systems, the genetic basis of eye development and function is well understood only in Drosophila melanogaster. We describe an eye transcriptome for the planarian Schmidtea mediterranea. Planarian photoreceptors expressed orthologs of genes required for phototransduction and microvillus structure in Drosophila and vertebrates, and optic pigment cells expressed solute transporters and melanin synthesis enzymes similar to those active in the vertebrate retinal pigment epithelium. Orthologs of several planarian eye genes, such as bestrophin-1 and Usher syndrome genes, cause eye defects in mammals when perturbed and were not previously described to have roles in invertebrate eyes. Five previously undescribed planarian eye transcription factors were required for normal eye formation during head regeneration. In particular, a conserved, transcription-factor-encoding ovo gene was expressed from the earliest stages of eye regeneration and was required for regeneration of all cell types of the eye.
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