Evidence map›Paper›PMID 22884038›Full record

ArticleJournal of biomechanics2012

Contributions of muscles to mediolateral ground reaction force over a range of walking speeds.

Chand T John, Ajay Seth, Michael H Schwartz, Scott L Delp

Abstract read
In one paragraph

Article in Journal of biomechanics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chand T JohnDepartment of Computer Science, Stanford University, Stanford, CA 94305-5450, USA.
Ajay Seth
Michael H Schwartz
Scott L Delp

Funding

Physics-based Simulation of Biological Structures(RMI)U54GM072970 · NIGMS · STANFORD UNIVERSITY · PI PANDE, VIJAY S · 2004 to 2013
$33.5M
National Center for Simulation in Rehabilitation ResearchR24HD065690 · NICHD · STANFORD UNIVERSITY · PI DELP, SCOTT L · 2010 to 2014
$4.2M
Muscle Function in Deformed &Surgically Altered LimbsR01HD033929 · NICHD · STANFORD UNIVERSITY · PI DELP, SCOTT L · 1996 to 2010
$2.0M
Predoctoral Training Bioinformatics/Computational Biol.T32GM063495 · NIGMS · STANFORD UNIVERSITY · PI ALTMAN, RUSS BIAGIO · 2001 to 2009
$1.7M
Development of a SimTK-based framework for hemiparetic walking assessmentR01NS055380 · NINDS · UNIVERSITY OF TEXAS AT AUSTIN · PI NEPTUNE, RICHARD R · 2007 to 2010
$1.3M
NICHD NIH HHS R01 HD033929NICHD NIH HHS R01HD033929NICHD NIH HHS R24 HD065690NICHD NIH HHS R24HD065690NIGMS NIH HHS GM63495NIGMS NIH HHS T32 GM063495NIGMS NIH HHS U54 GM072970NINDS NIH HHS R01 NS055380NINDS NIH HHS R01NS55380
6 · The paper itself

Abstract

Impaired control of mediolateral body motion during walking is an important health concern. Developing treatments to improve mediolateral control is challenging, partly because the mechanisms by which muscles modulate mediolateral ground reaction force (and thereby modulate mediolateral acceleration of the body mass center) during unimpaired walking are poorly understood. To investigate this, we examined mediolateral ground reaction forces in eight unimpaired subjects walking at four speeds and determined the contributions of muscles, gravity, and velocity-related forces to the mediolateral ground reaction force by analyzing muscle-driven simulations of these subjects. During early stance (0-6% gait cycle), peak ground reaction force on the leading foot was directed laterally and increased significantly (p<0.05) with walking speed. During early single support (14-30% gait cycle), peak ground reaction force on the stance foot was directed medially and increased significantly (p<0.01) with speed. Muscles accounted for more than 92% of the mediolateral ground reaction force over all walking speeds, whereas gravity and velocity-related forces made relatively small contributions. Muscles coordinate mediolateral acceleration via an interplay between the medial ground reaction force contributed by the abductors and the lateral ground reaction forces contributed by the knee extensors, plantarflexors, and adductors. Our findings show how muscles that contribute to forward progression and body-weight support also modulate mediolateral acceleration of the body mass center while weight is transferred from one leg to another during double support.

Indexed as

Models, BiologicalAdolescentChildFemaleGravitationHumansMaleMuscle, SkeletalPostural BalanceWalking

Identifiers

PMID22884038
PMCPMC3438315

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.