ArticleMolecular microbiology2012
Identification of a complex genetic network underlying Saccharomyces cerevisiae colony morphology.
Article in Molecular microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 71 citations in OpenAlex.
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- Analysis of the response mechanism in lipid degradation of key gene LDH1 knockout strains of Saccharomyces cerevisiae under levulinic acid stress.Archives of microbiology · 2025Article
- Genetic properties underlying transcriptional variability across different perturbations.Nature communications · 2025Article
- A highly conserved tRNA modification contributes toMicrobiology spectrum · 2024Article
- Integrative analysis of yeast colony growth.Communications biology · 2024Article
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- Ncs2* mediates in vivo virulence of pathogenic yeast through sulphur modification of cytoplasmic transfer RNA.Nucleic acids research · 2023Article
- Inheritance of epigenetic transcriptional memory through read-write replication of a histone modification.Annals of the New York Academy of Sciences · 2023Review
- High-throughput approaches to functional characterization of genetic variation in yeast.Current opinion in genetics & development · 2022Review
- Quantifying yeast colony morphologies with feature engineering from time-lapse photography.Scientific data · 2022Article
- Unlocking the functional potential of polyploid yeasts.Nature communications · 2022Article
- Truth in wine yeast.Microbial biotechnology · 2022Review
- FLO11, a Developmental Gene Conferring Impressive Adaptive Plasticity to the YeastPathogens (Basel, Switzerland) · 2021Review
- Spatially structured yeast communities: Understanding structure formation and regulation with omics tools.Computational and structural biotechnology journal · 2021Review
- Variation, Variegation and Heritable Gene Repression inFrontiers in genetics · 2021Review
- Vinification withoutMicroorganisms · 2020Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
When grown on solid substrates, different microorganisms often form colonies with very specific morphologies. Whereas the pioneers of microbiology often used colony morphology to discriminate between species and strains, the phenomenon has not received much attention recently. In this study, we use a genome-wide assay in the model yeast Saccharomyces cerevisiae to identify all genes that affect colony morphology. We show that several major signalling cascades, including the MAPK, TORC, SNF1 and RIM101 pathways play a role, indicating that morphological changes are a reaction to changing environments. Other genes that affect colony morphology are involved in protein sorting and epigenetic regulation. Interestingly, the screen reveals only few genes that are likely to play a direct role in establishing colony morphology, with one notable example being FLO11, a gene encoding a cell-surface adhesin that has already been implicated in colony morphology, biofilm formation, and invasive and pseudohyphal growth. Using a series of modified promoters for fine-tuning FLO11 expression, we confirm the central role of Flo11 and show that differences in FLO11 expression result in distinct colony morphologies. Together, our results provide a first comprehensive look at the complex genetic network that underlies the diversity in the morphologies of yeast colonies.
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Registered trials
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