ArticleCardiovascular diabetology2012
GC-MS analysis and screening of antidiabetic, antioxidant and hypolipidemic potential of Cinnamomum tamala oil in streptozotocin induced diabetes mellitus in rats.
Article in Cardiovascular diabetology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 125 citations in OpenAlex.
- Optimizing sonication-assisted hydrodistillation of Cinnamomum tamala essential oil using response surface methodology and artificial neural network modeling.Scientific reports · 2026Article
- The Antidiabetic Mechanisms of Cinnamon Extract: Insights from Network Pharmacology, Gut Microbiota, and Metabolites.Current issues in molecular biology · 2025Article
- Protective Effect of Cinnamon (Cinnamomum zeylanicum) Extract on the Sperm Quality During Cool Storage of Ram Semen.Veterinary medicine and science · 2025Article
- Antidiabetic and Anti-Inflammatory Effect ofPharmaceuticals (Basel, Switzerland) · 2024Article
- Chemical fingerprinting and multicomponent quantitative analysis for quality control ofHeliyon · 2024Article
- Cinnamaldehyde ameliorates STZ-induced diabetes through modulation of autophagic process in adipocyte and hepatic tissues on rats.Scientific reports · 2024Article
- Advances in pharmacological effects and mechanism of action of cinnamaldehyde.Frontiers in pharmacology · 2024Review
- Electrophilic Agonists Modulate the Transient Receptor Potential Ankyrin-1 Channels Mediated by Insulin and Glucagon-like Peptide-1 Secretion for Glucose Homeostasis.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Antimicrobial potential of IndianSaudi journal of biological sciences · 2023Article
- Effect of crocin and treadmill exercise on oxidative stress and heart damage in diabetic rats.PloS one · 2023Article
- A Comparative Study on Improving Streptozotocin-Induced Type 2 Diabetes in Rats by Hydrosol, Extract and Nanoemulsion Prepared from Cinnamon Leaves.Antioxidants (Basel, Switzerland) · 2022Article
- Botanical Interventions to Improve Glucose Control and Options for Diabetes Therapy.SN comprehensive clinical medicine · 2021Article
- An immunohistochemical examination of cinnamon extract administration on distribution of NGF (nerve growth factor) and Trk-A (tyrosine kinase-A) receptor for diabetic rats with pancreatic tissue.Turkish journal of medical sciences · 2021Article
- The Role of Essential Oils and Their Main Compounds in the Management of Cardiovascular Disease Risk Factors.Molecules (Basel, Switzerland) · 2021Review
- Contributions from Mexican Flora for the Treatment of Diabetes Mellitus: Molecules ofMolecules (Basel, Switzerland) · 2021Review
- Ethnomedicinal Value of Antidiabetic Plants in Bangladesh: A Comprehensive Review.Plants (Basel, Switzerland) · 2021Review
- Review
- Protective effects of Cinnamomum verum, Cinnamomum cassia and cinnamaldehyde against 6-OHDA-induced apoptosis in PC12 cells.Molecular biology reports · 2020Article
- Keap1/Nrf2/HO-1 signaling pathway contributes to p-chlorodiphenyl diselenide antidepressant-like action in diabetic mice.Psychopharmacology · 2020Article
- Effects of Cinnamon (Journal of lipids · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aim of the studyThis study was made to investigate the antidiabetic, antioxidant and hypolipidemic potential of Cinnamomum tamala, (Buch.-Ham.) Nees & Eberm (Tejpat) oil (CTO) in streptozotocin (STZ) induced diabetes in rats along with evaluation of chemical constituents. MATERIALS AND
methodsThe GC-MS (Gas chromatography-mass spectrometry) analysis of the oil showed 31 constituents of which cinnamaldehyde was found the major component (44.898%). CTO and cinnamaldehyde was orally administered to diabetic rats to study its effect in both acute and chronic antihyperglycemic models. The body weight, oral glucose tolerance test and biochemical parameters viz. glucose level, insulin level, liver glycogen content, glycosylated hemoglobin, total plasma cholesterol, triglyceride and antioxidant parameters were estimated for all treated groups and compared against diabetic control group.
resultsCTO (100 mg/kg and 200 mg/kg), cinnamaldehyde (20 mg/kg) and glibenclamide (0.6 mg/kg) in respective groups of diabetic animals administered for 28 days reduced the blood glucose level in streptozotocin induced diabetic rats. There was significant increase in body weight, liver glycogen content, plasma insulin level and decrease in the blood glucose, glycosylated hemoglobin and total plasma cholesterol in test groups as compared to control group. The results of CTO and cinnamaldehyde were found comparable with standard drug glibenclamide. In vitro antioxidant studies on CTO using various models showed significant antioxidant activity. In vivo antioxidant studies on STZ induced diabetic rats revealed decreased malondialdehyde (MDA) and increased reduced glutathione (GSH).
conclusionThus the investigation results that CTO has significant antidiabetic, antioxidant and hypolipidemic activity.
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