ArticleRespirology (Carlton, Vic.)2012
Mitigation of radiation induced pulmonary vascular injury by delayed treatment with captopril.
Article in Respirology (Carlton, Vic.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Association of pulmonary artery radiation with pulmonary hypertension after lung cancer radiotherapy.Thorax · 2026Article
- Review
- Radiomitigators: Breakthroughs in Post-Radiation Recovery.Antioxidants (Basel, Switzerland) · 2026Review
- Advances in noninvasive imaging for detecting radiation-induced lung injury (RILI).International journal of radiation biology · 2025Review
- Exploration of radiation-induced lung injury, from mechanism to treatment: a narrative review.Translational lung cancer research · 2022Review
- Radiation-induced cardiac side-effects: The lung as target for interacting damage and intervention.Frontiers in oncology · 2022Review
- Ramipril reduces incidence and prolongates latency time of radiation-induced rat myelopathy after photon and carbon ion irradiation.Journal of radiation research · 2020Article
- Targets for protection and mitigation of radiation injury.Cellular and molecular life sciences : CMLS · 2020Review
- Mitigation of Radiation-induced Pneumonitis and Lung Fibrosis using Alpha-lipoic Acid and Resveratrol.Anti-inflammatory & anti-allergy agents in medicinal chemistry · 2020Article
- Mitigation of Radiation-Induced Lung Pneumonitis and Fibrosis Using Metformin and Melatonin: A Histopathological Study.Medicina (Kaunas, Lithuania) · 2019Article
- Cardiac Remodeling and Reversible Pulmonary Hypertension During Pneumonitis in Rats after 13-Gy Partial-Body Irradiation with Minimal Bone Marrow Sparing: Effect of Lisinopril.Health physics · 2019Article
- A Rat Model of Radiation Vasculitis for the Study of Mesenchymal Stem Cell-Based Therapy.BioMed research international · 2019Article
- Novel Indications for Commonly Used Medications as Radiation Protectants in Spaceflight.Aerospace medicine and human performance · 2017Review
- Novel concepts in radiation-induced cardiovascular disease.World journal of cardiology · 2016Review
- Addressing the Symptoms or Fixing the Problem? Developing Countermeasures against Normal Tissue Radiation Injury.Radiation research · 2016Review
- Role of matrix metalloproteinases in radiation-induced lung injury in alveolar epithelial cells of Bama minipigs.Experimental and therapeutic medicine · 2015Article
- Whole-thorax irradiation induces hypoxic respiratory failure, pleural effusions and cardiac remodeling.Journal of radiation research · 2015Article
- Targeting the Renin-angiotensin system combined with an antioxidant is highly effective in mitigating radiation-induced lung damage.International journal of radiation oncology, biology, physics · 2014Article
- Effects of ionizing radiation on biological molecules--mechanisms of damage and emerging methods of detection.Antioxidants & redox signaling · 2014Review
- Enalapril mitigates radiation-induced pneumonitis and pulmonary fibrosis if started 35 days after whole-thorax irradiation.Radiation research · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
objectiveA single dose of 10 Gy radiation to the thorax of rats results in decreased total lung angiotensin-converting enzyme (ACE) activity, pulmonary artery distensibility and distal vascular density while increasing pulmonary vascular resistance (PVR) at 2 months post-exposure. In this study, we evaluate the potential of a renin-angiotensin system (RAS) modulator, the ACE inhibitor captopril, to mitigate this pulmonary vascular damage.
methodsRats exposed to 10 Gy thorax only irradiation and age-matched controls were studied 2 months after exposure, during the development of radiation pneumonitis. Rats were treated, either immediately or 2 weeks after radiation exposure, with two doses of the ACE inhibitor, captopril, dissolved in their drinking water. To determine pulmonary vascular responses, we measured pulmonary haemodynamics, lung ACE activity, pulmonary arterial distensibility and peripheral vessel density.
resultsCaptopril, given at a vasoactive, but not a lower dose, mitigated radiation-induced pulmonary vascular injury. More importantly, these beneficial effects were observed even if drug therapy was delayed for up to 2 weeks after exposure.
conclusionsCaptopril resulted in a reduction in pulmonary vascular injury that supports its use as a radiomitigator after an unexpected radiological event such as a nuclear accident.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.