ArticleCell proliferation2012
Identification of microRNA-regulated autophagic pathways in plant lectin-induced cancer cell death.
Article in Cell proliferation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 32 citations in OpenAlex.
- Integrated bioinformatics and deep learning (MLP) approach reveals a novel five miRNA prognostic signature in uveal melanoma.Scientific reports · 2025Article
- Autophagy Regulators in Cancer.International journal of molecular sciences · 2023Review
- Navigating Multi-Scale Cancer Systems Biology Towards Model-Driven Clinical Oncology and Its Applications in Personalized Therapeutics.Frontiers in oncology · 2021Review
- [Expression and significance of microRNA-125b in tongue squamous cell carcinoma].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2020Article
- Serum miR-542-3p as a prognostic biomarker in osteosarcoma.Cancer biomarkers : section A of Disease markers · 2018Article
- Plant Lectins Targeting O-Glycans at the Cell Surface as Tools for Cancer Diagnosis, Prognosis and Therapy.International journal of molecular sciences · 2017Review
- The role of microRNAs in intrahepatic cholangiocarcinoma.Journal of cellular and molecular medicine · 2017Review
- Role of Epigenetics in Uveal Melanoma.International journal of biological sciences · 2017Review
- Deconvoluting the complexity of microRNAs in autophagy to improve potential cancer therapy.Cell proliferation · 2016Review
- miR-421 is a diagnostic and prognostic marker in patients with osteosarcoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- MicroRNA-613 inhibited ovarian cancer cell proliferation and invasion by regulating KRAS.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Identification of Novel Pathways in Plant Lectin-Induced Cancer Cell Apoptosis.International journal of molecular sciences · 2016Article
- MicroRNA expression and its implications for diagnosis and therapy of tongue squamous cell carcinoma.Journal of cellular and molecular medicine · 2016Review
- miR-372 suppresses tumour proliferation and invasion by targeting IGF2BP1 in renal cell carcinoma.Cell proliferation · 2015Article
- Review
- Lectins with potential for anti-cancer therapy.Molecules (Basel, Switzerland) · 2015Review
- Plant lectins, from ancient sugar-binding proteins to emerging anti-cancer drugs in apoptosis and autophagy.Cell proliferation · 2015Review
- MicroRNA-411 inhibited matrix metalloproteinase 13 expression in human chondrocytes.American journal of translational research · 2015Article
- MiR-506 suppresses tumor proliferation and invasion by targeting FOXQ1 in nasopharyngeal carcinoma.PloS one · 2015Article
- UNC51-like kinase 1, autophagic regulator and cancer therapeutic target.Cell proliferation · 2014Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesPlant lectins, carbohydrate-binding proteins of non-immune origin, have recently been reported to induce programmed cell death (including apoptosis and autophagy) in many types of cancer cells. MicroRNAs (miRNAs), small, non-coding endogenous RNAs, ~22 nucleotides (nt) in length, have been well characterized to play essential roles in regulation of the autophagy process in cancer; however, how these miRNAs regulate autophagic pathways in plant lectin-induced cancer cells, still remains an enigma. MATERIALS AND
methodsIdentification of microRNA-regulated autophagic pathways was carried out using a series of elegant systems - biology and bioinformatics approaches, such as network construction, hub protein identification, targeted microRNA prediction, microarray analyses and molecular docking.
resultsWe computationally constructed the human autophagic protein-protein interaction (PPI) network, and further modified this network into a plant lectin-induced network. Subsequently, we identified 9 autophagic hub proteins and 13 relevant oncogenic and tumour suppressive miRNAs, that could regulate these aforementioned targeted autophagic hub proteins, in human breast carcinoma MCF-7 cells. In addition, we confirmed that plant lectins could block the sugar-containing receptor EGFR-mediated survival pathways, involved in autophagic hub proteins and relevant miRNAs, thereby ultimately culminating in autophagic cell death.
conclusionsThese results demonstrate that network-based identification of microRNAs modulate autophagic pathways in plant lectin-treated cancer cells, which may shed new light on the discovery of plant lectins as potent autophagic inducers, for cancer drug discovery.
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