ArticleBrain pathology (Zurich, Switzerland)2013
Characterization of thorn-shaped astrocytes in white matter of temporal lobe in Alzheimer's disease brains.
Article in Brain pathology (Zurich, Switzerland), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Systematic review of human post-mortem immunohistochemical studies and bioinformatics analyses unveil the complexity of astrocyte reaction in Alzheimer's disease.Neuropathology and applied neurobiology · 2022Pooled it
- Exposure to fibrillar proteins leads to widespread infiltration but only mild tau pathology in cortical organoids.iScience · 2026Article
- DHCR24 Knockdown Induces Tau Hyperphosphorylation at Thr181, Ser199, Ser262, and Ser396 Sites via Activation of the Lipid Raft-Dependent Ras/MEK/ERK Signaling Pathway in C8D1A Astrocytes.Molecular neurobiology · 2022Article
- Prevalence of chronic traumatic encephalopathy in the Sydney Brain Bank.Brain communications · 2022Article
- Space-occupying brain lesions, trauma-related tau astrogliopathy, and ARTAG: a report of two cases and a literature review.Acta neuropathologica communications · 2021Review
- Beta-Secretase 1 Underlies Reactive Astrocytes and Endothelial Disruption in Neurodegeneration.Frontiers in cellular neuroscience · 2021Article
- Tau immunophenotypes in chronic traumatic encephalopathy recapitulate those of ageing and Alzheimer's disease.Brain : a journal of neurology · 2020Article
- Language and spatial dysfunction in Alzheimer disease with white matter thorn-shaped astrocytes.Neurology · 2020Article
- Relevance of host tau in tau seeding and spreading in tauopathies.Brain pathology (Zurich, Switzerland) · 2020Article
- Aging-related tau astrogliopathy (ARTAG): not only tau phosphorylation in astrocytes.Brain pathology (Zurich, Switzerland) · 2018Article
- Sisyphus in Neverland.Journal of Alzheimer's disease : JAD · 2018Article
- Deciphering the Astrocyte Reaction in Alzheimer's Disease.Frontiers in aging neuroscience · 2018Review
- Diversity of astroglial responses across human neurodegenerative disorders and brain aging.Brain pathology (Zurich, Switzerland) · 2017Article
- Protein astrogliopathies in human neurodegenerative diseases and aging.Brain pathology (Zurich, Switzerland) · 2017Review
- Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy.Acta neuropathologica · 2016Review
- Impaired APP activity and altered Tau splicing in embryonic stem cell-derived astrocytes obtained from an APPsw transgenic minipig.Disease models & mechanisms · 2015Article
- Chronic traumatic encephalopathy: a spectrum of neuropathological changes following repetitive brain trauma in athletes and military personnel.Alzheimer's research & therapy · 2014Review
- The neuropathology of sport.Acta neuropathologica · 2014Review
- The spectrum of disease in chronic traumatic encephalopathy.Brain : a journal of neurology · 2013Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thorn-shaped astrocytes (TsA) are mainly localized in the periventricular white matter of the temporal lobe in a subgroup of aged individuals usually in the context of Alzheimer's disease (AD). Immunohistochemistry of TsA shows 4Rtau deposition, tau phosphorylation at different sites recognized with phosphospecific anti-tau antibodies Thr181, Ser202, Ser214, Thr231, Ser396, Ser422, and clones AT8 and PHF-1, and conformational changes revealed with Alz50 and MC-1 antibodies; TsA are also immunostained with antibodies to active tau kinases MAPK/ERK-P, SAPK/JNK-P, p38-P and GSK-3β. These findings are common to neurofibrillary tangles in AD. However, TsA are not stained with 3Rtau antibodies, and they are seldom stained or not at all with phosphospecific tauSer262 and with Tau-C3 antibody, which recognizes the latter tau truncation at aspartic acid 421. Previous studies have shown that tau phosphorylation at Ser262 reduces tau binding to microtubules and increases caspase-3 activity, whereas tau truncation at aspartic acid 421 is associated with tau ubiquitination, and toxic effects of tau. In this line, ubiquitin is not accumulated in TsA, and in situ end-labeling of nuclear DNA fragmentation shows absence of degeneration in TsA. These observations support the concept that tau lesions in neurons differ from those seen in TsA in AD.
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