ArticleAnalytical chemistry2012
Tip-enhanced Raman detection of antibody conjugated nanoparticles on cellular membranes.
Article in Analytical chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Nanoscale chemical analysis of 2D molecular materials using tip-enhanced Raman spectroscopy.Nanoscale · 2023Review
- Nanoscale Chemical Imaging of Human Cell Membranes Using Tip-Enhanced Raman Spectroscopy.Angewandte Chemie (International ed. in English) · 2022Article
- A Wide-Field Imaging Approach for Simultaneous Super-Resolution Surface-Enhanced Raman Scattering Bioimaging and Spectroscopy.ACS measurement science au · 2022Article
- Probing Membrane Receptors with Enhanced Raman Imaging.Proceedings of SPIE--the International Society for Optical Engineering · 2018Article
- Plasmon-Mediated Drilling in Thin Metallic Nanostructures.ACS omega · 2018Article
- Spectroscopic Imaging at the Nanoscale: Technologies and Recent Applications.Analytical chemistry · 2018Review
- Probing Membrane Receptor-Ligand Specificity with Surface- and Tip- Enhanced Raman Scattering.Analytical chemistry · 2017Article
- Selective Detection of RGD-Integrin Binding in Cancer Cells Using Tip Enhanced Raman Scattering Microscopy.Analytical chemistry · 2016Article
- Targeted-TERS detection of integrin receptors on human cancer cells.Cancer cell & microenvironment · 2016Article
- The substrate matters in the Raman spectroscopy analysis of cells.Scientific reports · 2015Article
- Experimental correlation of electric fields and Raman signals in SERS and TERS.Proceedings of SPIE--the International Society for Optical Engineering · 2015Article
- Selective TERS detection and imaging through controlled plasmonics.Faraday discussions · 2015Article
- Imaging Electric Fields in SERS and TERS Using the Vibrational Stark Effect.The journal of physical chemistry letters · 2013Article
- The chemical origin of enhanced signals from tip-enhanced Raman detection of functionalized nanoparticles.The Analyst · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Tip enhanced Raman scattering (TERS) microscopy is used to image antibody conjugated nanoparticles on intact cellular membranes. The combination of plasmonic coupling and the resultant electric field obtained from intermediate focusing of a radially polarized source gives rise to Raman images with spatial resolution below 50 nm. Finite element method calculations are used to explain the origins of the observed image resolution and spectroscopic signals. The observed Raman scattering provides information about the biomolecules present near the nanoparticle probes. The results show that aggregates of nanoparticles produce spectroscopic results similar to those reported from other surface enhanced Raman spectroscopies, e.g., shell isolated nanoparticle enhanced Raman spectroscopy (SHINERS) and aggregated nanoparticles; however, TERS enables the detection of isolated nanoparticles on cell membranes where the observed spectra provide information about the interaction of the specific biomolecule conjugated to the nanoparticle probe. These measurements present a new technique for exploring biomolecular interactions on the surface of cells and tissue.
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Registered trials
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